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Chronic, Subtle, Systemic Inflammation

One possible sneaky cause of puzzling chronic pain

Paul Ingraham, updated

SHOW SUMMARY
Close-up photograph of hot coals, representing inflammation.

Do you seem to have more than your fair share of aches and pains? It’s probably not your imagination, and there are many possible explanations for chronic pain, but this article is about one of the most insidious and interesting. It’s most relevant to you if you’re struggling with your weight and/or severe chronic stress … or if you’re just getting older. So really quite a lot of people.

Everyone over 40 knows that it gets more uncomfortable to get out of beds and chairs as we age, and we’re plagued by ever more pains that come and go without much rhyme or reason. Most people chalk this all up to “arthritis,” but that’s rarely a significant factor until much later in life.1 Conditions like fibromyalgia and myofascial pain syndrome, as common as they are, can’t account for all of it. Some medications cause widespread sensitivity as a side effect,2 but that still doesn’t explain such a widespread problem either. So what’s going on?

A little bit of inflammation spread all over the place is one possible culprit. And I have to strongly emphasize that this is an unproven idea, and there is plenty of guessing in this article: well-informed and evidence-based guessing, but guessing. Nevertheless, it may be one of the major fundamental mechanisms of vulnerability to chronic pain, along with central sensitization.

Chronic low grade inflammation is increasingly seen as a part of other orthopaedic conditions such as osteoarthritis — once considered a ‘cold’ wear and tear problem (as opposed to the far more overt and ‘hot’ inflammation of rheumatoid arthritis).

~ Summer is coming — Frozen Shoulder, Cocks (Noijam.com)

Why would anyone be a little bit inflamed all over?

To some extent inflammation is just a part of life, the inevitable cost of having an immune system. Like a society must balance police and military powers against civil liberties, evolution has had to juggle the pros and cons of a potent defense system. There’s probably always some inflammation going on somewhere in the body, and it even fluctuates in natural daily rhythms. It’s suppressed at night, for instance, which has many clinical implications, such as why morning pain may be such a familiar annoyance for humans.3

For a variety of reasons, it can get a bit out of hand. Especially as we age.

Most chronic low-grade inflammation is probably an aging thing. This has a name: it is quaintly known as “inflammaging.”4 To be old is to be inflamed! And to be inflamed excessively may be synomous with premature aging … which is probably affected by both your genes and lifestyle. Things that are unhealthy (smoking, inactivity, stress, sleep deprivation) don’t so much make you feel old as literally age you.

Exactly why we get inflamed is where the mystery lives.

It’s not the years, honey. It’s the mileage.

~ Indiana Jones

Metabolic syndrome

A lot of inflammaging is probably a consequence of “metabolic syndrome,” [NIH] a set of biological dysfunctions strongly linked to poor fitness, obesity, and aging. It is the roots of heart disease and diabetes. And we also know that metabolic syndrome is clearly associated with at least some common pain problems, like neck pain5 and back pain.6

Or maybe it’s the other way around, and chronic inflammation drives metabolic syndrome. Definitely maybe.7

Stress and metabolic syndrome

Metabolic syndrome in turn is probably linked to severe chronic stress … or even stress that happened long ago, during childhood.8 It’s also quite possible that stress is inflammatory independently of metabolic syndrome (if they can be separated). The role of stress is too complex, indirect, and long-term for clarity, but it’s a near certainty that it does have a role. I will return to this topic below, because it’s of great importance: it suggests that chronic low-grade inflammation might not be limited to the metabolic syndrome stereotype of “old, fat, unfit.”

From here, the waters only get muddier, the speculation thicker.

Chronic subtle infections

Inflammaging may worsen with time as we accumulate infections and their consequences. There are many pathogens and other invaders we know about that set up shop in the human body forever — “tenants” we cannot evict. The obvious ones are famous (e.g. herpes, measles, HIV, etc). For every obvious one, there might be several subtler ones that only mildly arouse our defenses, infections that will never be diagnosed, let alone treated. As we move through life, we encounter more and more of these pathogens, some tougher than others. Accumulate enough of them, et voila, “inflammaging.”

Another scenario: there’s good evidence that a weak immune system can also allow some common minor infections to “reactivate” after lying dormant in our cells for years or even decades.9

But we may carry on suffering from infections even when when we successfully fight them off.

Autoimmunity and collateral damage: antibodies are forever

Autoimmune disease was originally thought of a baffling biological blooper: the body mysteriously attacking itself, the “why are you hitting yourself?” school of pathology.10 Some autoimmune disease may indeed be perverse self-abuse, but there is a more modern perspective, a hypothesis that autoimmune disease is mostly the price of doing business: collateral damage from unavoidable, ongoing battles with pathogens.

Or, worse, it could be collateral damage from battles that ended long ago, like stepping on a land mine from an old war.12

We make new antibodies for every pathogen (and other antigens, like allergens). Sometimes, those antibodies are not a perfect match for their target alone: they might also be match for a few of our own proteins, causing our immune systems to spend the rest of our lives over-reacting to healthy tissues that “look” a little bit similar to that old nemesis. The more wee beasties we fight off, the more potential there is for random, on-going, low-grade inflammation here there and everywhere.

Allergies

Interestingly, allergies often start in middle age. Hmmmm. The thot plickens.

Autoimmune disease is basically an allergy to yourself, an immune system reaction to a non-toxic foreign substance in the body, something harmless to one person but irritating or even deadly to the next. The immune system can be a terrible thing when incorrectly activated.

Inflammaging could also be the consequence of an escalating number of minor allergies — another kind of collateral damage. As we build up a collection of defenses against infection (antibodies), directly inspired by all the antigens we’ve “met” (both pathogens and allergens), those defenses almost certainly start reacting to a wider range of foreign substances in addition to some of our own proteins.

Pollutants

Pollutants are probably what most regular people hope they can “detox.” Historically, the best specific candidates would be the persistent organic pollutants like pesticides, flame retardants, and polychlorinated biphenyls (PCBs, now banned, but formerly ubiquitous in many plastics). Lead is also an alarmingly common environmental poison, much in the news a lot lately.

And there are always new pollutants. Surgical implants are an interesting example: they can break down in the body, causing widespread inflammation to varying degrees, a complication that can be extremely serious, but which almost certainly exists in many other people to a less obvious degree. Awareness of this problem started with a surprisingly recent disaster with metal-on-metal joint implants that poisoned people,14 but that was the tip of the iceberg: poorly designed and regulated surgical implants are a major concern (especially textile/fabric meshes).

There may also be similar and subtler sources of pollutants, like the routine consumption of microplastics — microscopic particles of garbage plastic — a topic much in the news lately. They probably aren’t as dangerous as disintegratin surgical implants, but it’s unlikely that they are completely safe either.

So all of these things, and probably more, can indeed found in our environment and our bodies, where they mostly get trapped in fat and otherwise sequestered — but they can also potentially be a source of chronic inflammation. We would certainly “detox” these pollutants if we could, but in most cases we probably cannot: the massive detox industry is almost pure bullshit, along with basically all popular beliefs about detoxing. For instance, we cannot sweat out toxins,15 or suck them out our bodies with Epsom salts baths.16

Can low-grade inflammation be diagnosed with blood tests?

A lot of inflammation is not easy to detect. It may hide effectively in specific tissues and systems, only detectable with complicated, expensive, invasive testing. This is one of the main reasons that some diseases have been so mysterious for so long.

There are more accessible blood tests that are quite sensitive to various signs of inflammation, but — because biology is messy — they are not super reliable, and even people with serious inflammatory diseases do not always get a clear result.

Many tests are not available as clinical tests for ordinary folks at all; they’ve just been used by scientists to show that:17

concentrations of inflammatory factors in these conditions are overall slightly higher than in healthy populations, but still remain in the healthy ranges. It is therefore hard to determine whether a specific patient exhibits ‘low-grade inflammation.’

Nevertheless, it’s worth asking your doctor. In particular, check your “CRP” (C-reactive protein). This is a common and easy test, and who knows: you might discover that you have not-so-low-grade inflammation.

Inflammation and fibromyalgia

The pain of fibromyalgia [Mayo] is an unexplained sensory dysfunction resulting in widespread oversensitivity to stimuli, exhaustion, and mental fog, among other things. It is stigmatized and both under and overdiagnosed,18 and all too often it is used as a way to dismiss the complaints of people who have unexplained pain, with the insinuation that they are “sensitive” or “dramatic” and don’t really have anything “real” wrong with their tissues. Of course this is great disservice to patients who don’t really have fibromyalgia and those who actually do.

But you’re not paranoid if they’re really after you, and you’re not “sensitive” if you’re actually inflamed. And fibromyalgia patients are probably actually inflamed!19 Inflammation may be why they are sensitized. Or perhaps even the other way around.

Fibromyalgia does routinely seem to involve sensitivity — the nervous system is over-reacting to stimuli — but inflammation constitutes an actual insult to tissues. Molecules produced by immune system activity, normally associated with infection and injury, are stimulating nerve endings (nociception). The information is sent to the spinal cord and brain for consideration, where the experience of pain may or may not be generated (but it probably will be).

Subjectively, it is nearly impossible to tell the difference between the pain of an oversensitive nervous system and the pain of a nervous system that is actually detecting inflammation all over.20 And yet the difference is enormous. For instance, Lasselin et al discovered in 2016 that chronic pain patients who are actually inflamed — confirmed with lab tests — are less responsive to behavioural therapy.21

Fibromyalgia may involve sensitivity and/or inflammation. Each of them might cause or aggravate the other, though it’s more likely that inflammation drives sensitization.

Inflammation and stress

The brain has a vast potential for sticking its nose into the immune system’s business.

~ Robert M Sapolsky, Why Zebras Don’t Get Ulcers, 2004, p. 144

There are strong but murky links between chronic pain and stress.22 We feel literally aged by adversity — we speak darkly of terrible events shaving time off our lifespans — and aging is nothing if not painful. We still don’t know if stress directly causes chronic pain and other health problems — though there are signs that it can23 — or if it “just” feeds back into it.24 It’s possible that low-grade chronic inflammation is one way that stress can become painful. It might even be the way.

Inflammation is immunity’s fingerprint, and we know (or strongly suspect) that “immunity is tuned by one’s emotions, personality, and social status as well as by other life style variables like sleep, nutrition, obesity, or exercise.”25 We know that nervous-wreck monkeys are inflamed, their immune systems a mess26 — and the same thing probably happens in humans. We suspect that rough childhoods may be a risk factor for several disorders that probably share inflammation as a mechanism.27

This is all a bit counterintuitive, because we “know” that stress suppresses immunity, and that stress hormones — coriticosteroids — are impressively anti-inflammatory. But that’s short term stress. It’s insanely complicated, but prolonged stress almost certainly does overstimulate the immune system and causes chronic excessive inflammation and autoimmune disease.

In the very short term (minutes), stress is indeed an immune stimulator (inflammatory). But then, almost right away, that effect gets reeled in to prevent collateral damage: you don’t want sustained immune stimulation! This suppressive effect is robust, and it’s why stress/steroids suppress inflammation. But in chronic stress, the stimulatory phase keeps happening over and over again, and the suppressive phase never quite catches up, and so overall immune system activation gradually ratchets up and up and up. Ergo, long term stress is inflammatory.28

Chart showing a sawtooth pattern of immune function increasing and decreasing with repeated stressors, but never quite recovering before increasing again, producing a steady upward trend.

“A schematic representation of how repeated stress increases the risk of autoimmune disease,” adapted from Sapolsky’s Why Zebras Don’t Get Ulcers.

The relationship between metabolic syndrome and inflammation is clear, but there may also be a link between metabolic syndrome and stress,29 and is almost certainly a link with sleep disturbance (which overlaps with stress, obviously).30 If true, it means that metabolic syndrome could affect millions of people who would not otherwise be likely victims.

We know that sleep deprivation (one of the most common forms of chronic stress) actually ages us in an objectively measurable way,31 and we know that age is strongly linked to inflammation (inflammaging).

There’s evidence that suggests that various soothing forms of treatment — yoga, meditation — may reduce chronic low-grade inflammation.32 Disclaimer: this is a very complicated, conflicted area of the scientific literature, possibly polluted with a lot of wishful thinking.

It’s really quite a lot of “circumstantial” evidence, isn’t it? This is hardly a complete tour of inflammation-stress science, but three times as much wouldn’t change the punchline: there’s probably a very complicated link.

Leaky gut syndrome: not a real cause of inflammation

This is a fake disease, based on the “hypothesis” — it barely deserves that word — that our modern diets are so full of irritating substances that our bowel is literally full of holes. Those substances, and gut bacteria as well, seep out into the abdominal cavity and provoke an autoimmune reaction. Leaky gut syndrome has been nominated as the root cause of nearly every unexplained syndrome there is, anything that can be plausibly linked to “inflammation.”

The cure? Eat like a prehistoric human. The autoimmune protocol (AIP) diet, which is a strict version of the trendiest of all trendy diets, the “paleo” diet: basically anything humans have eaten since the stone age is considered risky. This is obviously just an elimination diet that casts a wide net over everything you can put in your mouth that has ever been demonized, from food additives to gluten to dairy to nightshades. It’s a classic example of the naturalistic fallacy at work.

The theory is much more full of holes than anyone’s gut. The whole thing is nasty faddish pseudoscience being profitably marketed by all the usual suspects. For serious debunking, see the NHS or the Canadian GI Society. For a more whimsical and snarky one, which is probably all it really deserves, see Dr. Mark Crislip’s analysis.

What can you do about inflammation and inflammaging?

No one really knows, of course, and quite possibly nothing. But here are some ideas …

Fitness: Undoubtedly critical! Regular moderate exercise really is the closest thing we have to a miracle drug or a fountain of youth. The older you get, the more you should avoid the extremes: too much and too little are likely both a problem.

Portrait of Isaac Newton with meme-style caption: “Brother, do you even attempt to raise heavy objects against the force of gravity?”

Do you even lift? You should! Weight lifting specifically is linked to a lower risk of metabolic syndrome.33 It’s a more well-rounded and efficient workout than most people realize.34

Anti-inflammatory nutrition: It’s also possible to some extent to eat an anti-inflammatory diet — but that isn’t nearly as promising as it sounds. Things like Dr. Weil’s “Anti-Inflammatory Food Pyramid” are full of wishful thinking and make the science of anti-inflammatory diets seem way more complete and tidy than it actually is. Or there’s the autoimmune protocol (AIP) diet for “leaky gut syndrome,” which is all nonsense (see the leaky gut syndrome section). The smart money is on a diet that is just generally healthy, mostly by being low in obvious junk food (especially the ones that are a challenge to blood sugar regulation). Supplements and anti-inflammatory “superfoods” are mostly a pipe dream and the stuff of marketing.

Ketogenic diets and fasting: Just as scientifically sketchy as any other kind of anti-inflammatory dieting, but possibly worth experimenting with nevertheless. More below.

Reduce stress: Even though it’s not confirmed that there is a link between stress and inflammation, stress management has so many benefits that it is well pursuing regardless. You don’t have to meditate or do yoga (unless you want to). Often the best place to begin is troubleshooting major sources of chronic stress, like insomnia or anxiety.

Quitting bad habits: Consider finally ditching habits that are putting a strain on your biology, especially smoking (of course, smoking is a well known independent risk factor for pain), or drinking too much too regularly (anything more than a couple per day). Any kind of “hard living” is suspect. Coffee in reasonable doses, mercifully, is not an obvious suspect (it doesn’t dehydrate you, for instance35) — but if you’re drinking so much that it’s aggravating emotional stress with caffeine-powered agitation and anxiety, that’s another matter.

Vagus nerve stimulation sure sounds great (maybe a little too great): stimulate your vagus nerve with an implant, et voila, less systemic inflammation. There’s broad biological plausibility here, but almost no evidence. So far this hinges only on the results of Koopman et al, who tested it on humans and reported that “these results establish that vagus nerve stimulation targeting the inflammatory reflex modulates TNF production and reduces inflammation in humans.”36 Established, eh? Not without replication! That’s overconfident for sure — this badly needs replication before celebration.37 But it’s a genuinely interesting topic, I think.

Reducing inflammation with a ketogenic (very low carb) diet

Diets that force you to mainly burn fat for energy, instead of carbohydrates — a “ketogenic” diet, like the infamous Atkins diet — may be anti-inflammatory and/or de-sensitizing.

Ketogenic diets are so low in carbohydrates (sugars) that they force the body to burn fat for fuel, a novel metabolic state, which is well-known to treat epilepsy in some children. We can infer from that success story that the biology of this treatment might also have an effect on some kinds of inflammation and pain (especially neuropathic pain, the pain of damaged nerves38). Although highly speculative, there are some reasons to think this might work, and some indirect (animal) evidence that it does.39 Like seizures, some kinds of pain may involve “overexcited” neurons, and can be treated with anticonvulsant drugs. Ketone metabolism “produces fewer reactive oxygen species,” a contributor to inflammation; and it produces adenosine signalling, which is a suspected pain-killer in other contexts (exercise, possibly acupuncture).

This is a completely experimental treatment. However, like an anti-inflammatory diet (AKA “healthy”), it has a non-crazy rationale, and it’s safe and inexpensive to dabble in. As long as you don’t get extreme, the worst case scenario is putting up with a fussy and unpleasant change in eating habits. Nevertheless, I am obliged to suggest that you run this by your physician and/or a nutritionist.

You should probably spend at least two to four weeks in a ketogenic state to be sure that you’ve given it an adequate chance. If you see a clear reduction in symptoms, that’s a strong sign that it’s working. In a spirit of moderation, I do not recommend trying to stay in a ketogenic state for any more than a several weeks at a time, and you should probably take breaks — give your system a rest from ketogenesis once every week or two.

Fasting (or intermittent fasting)

Actual fasting might work simply because it includes ketogenesis, but it’s also harder and not as safe — so I’m less inclined to recommend it. But if you are keen on the idea fasting for whatever reason (e.g. meditative, emotional, spiritual reasons) it’s another possibility to consider. Of course, the subject of fasting is rife with pseudoscience and big claims, but here are two good sources to start with: Martin Berkhan’s LeanGains.com (start with his myths of fasting), and Dr. Bojan Kostevski’s thesis paper, “The Effects of Intermittent Fasting on Human and Animal Health.”

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About Paul Ingraham

Headshot of Paul Ingraham, short hair, neat beard, suit jacket.

I am a science writer, former massage therapist, and I was the assistant editor at ScienceBasedMedicine.org for several years. I have had my share of injuries and pain challenges as a runner and ultimate player. My wife and I live in downtown Vancouver, Canada. See my full bio and qualifications, or my blog, Writerly. You might run into me on Facebook or Twitter.

Related Reading

What’s new in this article?

Sixteen updates have been logged for this article since publication (2016). All PainScience.com updates are logged to show a long term commitment to quality, accuracy, and currency. more When’s the last time you read a blog post and found a list of many changes made to that page since publication? Like good footnotes, this sets PainScience.com apart from other health websites and blogs. Although footnotes are more useful, the update logs are important. They are “fine print,” but more meaningful than most of the comments that most Internet pages waste pixels on.

I log any change to articles that might be of interest to a keen reader. Complete update logging of all noteworthy improvements to all articles started in 2016. Prior to that, I only logged major updates for the most popular and controversial articles.

See the What’s New? page for updates to all recent site updates.

JuneAdded a section about pollutants and their potential contribution to inflammaging.

JuneAdded quite a bit of speculation about factors that might contribute to inflammaging, mainly related to immunity.

AprilNew section: “Leaky gut syndrome: not a real cause of inflammation.”

2018Summary of Sapolsky’s explanation for why chronic stress is inflammatory, plus a nice new chart. Good stuff! Answers to questions I have had myself for a looong time.

2018Added a bit more detail on anti-inflammatory foods and dieting.

2017Science update based a nice bit of good news about weight lifting reducing the risk of metabolic syndrome (Bakker et al).

2017Added interesting citation to Hussain et al, showing evidence of the metabolic/inflammatory roots of back pain.

2017Added interesting citation to Bäckryd et al, the first evidence of extensive inflammation in fibromyalgia patients.

2017Science update, added a citation about the link between metabolic syndrome and sleep disturbance (as a proxy for stress).

2017Revision and upgrades to the link between stress and inflammation: more citations, more ideas, more clarity.

2016New section devoted to exploration of the link between stress and inflammation.

2016Science update, mostly concerning the relationship between inflammation and stress.

2016New treatment option reviewed: vagus nerve stimulation.

2016Added mobile summary, and a “perspective” sidebar warning against snake oily imposters.

2016Added another plausible explanation for inflammaging: the reactivation or dormant common infections. Also added a citation link metabolic syndrome to neck pain.

2016Many miscellaneous minor improvements.

2016Publication.

Notes

  1. Not many middle-aged people have enough arthritis to account for the sheer number of variety of aches and pains that they often report. Arthritic pain is typically well localized to specific joints, and usually not serious in middle age (unless the joint is vulnerable to early arthritis due to an injury). BACK TO TEXT
  2. The main ones to watch out for are the bisphosphonates (Alendronate, risedronate, Actonel, Atelvia) and statins (Lipitor, Crestor, Mevacor, Zocor, Lescol). For more information, see 32 Surprising Causes of Pain. BACK TO TEXT
  3. Hand LE, Hopwood TW, Dickson SH, et al. The circadian clock regulates inflammatory arthritis. FASEB J. 2016 Aug. PubMed #27488122.  BACK TO TEXT
  4. Franceschi C, Campisi J. Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. J Gerontol A Biol Sci Med Sci. 2014 Jun;69 Suppl 1:S4–9. PubMed #24833586.  PainSci #53291.  “Human aging is characterized by a chronic, low-grade inflammation, and this phenomenon has been termed as "inflammaging." Inflammaging is a highly significant risk factor for both morbidity and mortality in the elderly people, as most if not all age-related diseases share an inflammatory pathogenesis. Nevertheless, the precise etiology of inflammaging and its potential causal role in contributing to adverse health outcomes remain largely unknown.” BACK TO TEXT
  5. Mäntyselkä P, Kautiainen H, Vanhala M. Prevalence of neck pain in subjects with metabolic syndrome—a cross-sectional population-based study. BMC Musculoskelet Disord. 2010;11:171. PubMed #20670458.  PainSci #53456.  This study found that neck pain is prevalent in people with metabolic syndrome. The relationship is definitely not necessarily causal, but it certainly might be. This evidence certainly suggests a need for more research to find out. BACK TO TEXT
  6. Hussain SM, Urquhart DM, Wang Y, et al. Fat mass and fat distribution are associated with low back pain intensity and disability: results from a cohort study. Arthritis Res Ther. 2017 Feb;19(1):26. PubMed #28183360.  PainSci #52908. 

    This important paper shows evidence of the metabolic roots of back pain, and perhaps other kinds of chronic pain as well. The majority (82%) of 5000 Australians reported back pain on a questionnaire, and in 27% of them it was bad enough to be disabling. When compared to their fat mass fat distribution — known indicators of metabolic disorders — a clear pattern emerged: back pain intensity and disability go up with measures of fat mass and distribution. This data does not suggest that weight is a “mechanical” problem — greater weight causing greater stress on spinal joints. Instead, it suggests that “systemic metabolic factors associated with adiposity play a major role in the pathogenesis of LBP.” The weight isn’t the problem, but the biochemistry of being out of shape.

    This is a particularly excellent example of what I mean when I argue that we need to look beyond trivial physical stresses and biomechanical factors to the messy “wet” factors in chronic pain, the things that make us more vulnerable to painvulnerable

    BACK TO TEXT
  7. Esposito K, Giugliano D. The metabolic syndrome and inflammation: association or causation? Nutr Metab Cardiovasc Dis. 2004 Oct;14(5):228–32. PubMed #15673055.  BACK TO TEXT
  8. Burke NN, Finn DP, McGuire BE, Roche M. Psychological stress in early life as a predisposing factor for the development of chronic pain: Clinical and preclinical evidence and neurobiological mechanisms. J Neurosci Res. 2016 Jul. PubMed #27402412.  “Early-life adversity increases the risk of developing a number of disorders, such as chronic pain, fibromyalgia, and irritable bowel syndrome.” BACK TO TEXT
  9. Bennett JM, Glaser R, Malarkey WB, et al. Inflammation and reactivation of latent herpesviruses in older adults. Brain Behav Immun. 2012 Jul;26(5):739–46. PubMed #22155500.  PainSci #53327.  “Persistent pathogens such as latent herpesviruses and chronic bacterial infections can act as a source of inflammation. Herpesviruses, including Epstein-Barr virus (EBV) and cytomegalovirus (CMV), establish latent infections following primary infection and reactivate when the cellular immune system is compromised.” In this study of 222 older adults (~64), activity of these two viruses was associated with more inflammatory markers (CRP and IL-6). “Thus, reactivation of multiple herpesviruses may drive inflammation and could contribute to poorer health among older adults.” BACK TO TEXT
  10. Autoimmune disease is inflammatory by definition, and is extremely unpredictable. Even full-blown autoimmune diseases are notoriously difficult to diagnose, because they tend to erratically affect many systems. It’s likely that some people have minor autoimmune disease, effectively undiagnosable. It’s not even a case of having “early” autoimmune disease: AD is so unpredictable that it might well permanently back off before getting severe enough to be diagnosed. BACK TO TEXT
  11. CBC.ca [Internet]. Quirks & Quarks. Have researchers been wrong about Alzheimer's? A new theory challenges the old story; 2018 Dec 8 [cited 19 Jun 16]. The infamous brain plaques of Alzheimer’s have always been a mystery. Evidence increasingly suggests that they are actually “nets” of a sophisticated infection-fighting strategy, designed to trap a common pathogen — but at a price that gets steeper over the years. BACK TO TEXT
  12. Microbeminded.com [Internet]. Proal A. Re-evaluating the theory of autoimmunity; 2019 June 6 [cited 19 Jun 19].

    This is a clear and concise summary of an intriguing and plausible hypothesis: that autoimmune disease is not caused by the body’s immune system “attacking itself,” but by collateral damage when the immune system fights infections with antibodies that also happen to match our own proteins. This may also be the explanation for “inflammaging”: as we accumulate antibodies from infections over the years, we basically start to get mild “autoimmune disease.”

    BACK TO TEXT
  13. www.newscientist.com [Internet]. Williams C. How to extinguish the inflammation epidemic; 2017 July 18 [cited 19 Jun 17].

    This article was really hot for a while. It has superficial credibility, but actually offers just a lot of oversimplified wishful thinking about inflammation as the one true cause of all of our problems, and a few unremarkable treatment suggestions. The author aggressively demonizes stress and “modern living” as the major cause of systematic inflammation (far beyond what the evidence can support), and gives only token attention to the devil in the details.

    In particular, she gets carried away with the idea that “inflammation has an off switch,” acknowledging too late that one of her expert sources, Dr. Derek Gilroy, “warns against getting too carried away with the resolvin story.” Dr. Gilroy’s quote (too little, too late) reads like a desperate attempt to undermine the story the author is hell-bent on telling:

    “The inflammation that we have in diseases like Alzheimer’s, cancer, autoimmune diseases like osteoarthritis, all of these are very different inflammatory processes,” he says. “It is hard for me to understand, given that there are many ways that a disease occurs, that they can resolve by the same mechanism.”

    Despite all of Williams’ optimism, the article coughs up a ridiculous list of five tepid inflammation-fighting recommendations: lose weight, relax, take aspirin in low doses, and — facepalm — stretch (a particularly desperate item, unwisely based on a scrap of evidence from Berrueta et al). While not all of these suggestions are not entirely meritless, they are blatantly a very weak sauce.

    BACK TO TEXT
  14. Cohen D. How safe are metal-on-metal hip implants? BMJ. 2012;344:e1410. PubMed #22374741.  PainSci #53447.  BACK TO TEXT
  15. Imbeault P, Ravanelli N, Chevrier J. Can POPs be substantially popped out through sweat? Environ Int. 2018 Feb;111:131–132. PubMed #29197670.  BACK TO TEXT
  16. Epsom salt in your bath is cheap and harmless and it makes the water feel “silkier,” but it’s unlikely that it has a therapeutic effect on aches and pains. Magnesium supplementation might be helpful for some patients with some kinds of pain, but not many others, and it’s doubtful that it can soak through the skin, and it definitely doesn’t “detox” anything. The soothing heat of a nice bath is probably the main source of health benefits. The case for the healing powers of Epsom salt is mostly made by people selling the stuff, or recommending it as casually and imprecisely as an old wives’ tale. See Does Epsom Salt Work? The science of Epsom salt bathing for recovery from muscle pain, soreness, or injury. BACK TO TEXT
  17. Lasselin, J. Low-grade inflammation and the brain. www.bodyinmind.org. Accessed 2016-12-08. BACK TO TEXT
  18. Walitt B, Katz RS, Bergman MJ, Wolfe F. Three-Quarters of Persons in the US Population Reporting a Clinical Diagnosis of Fibromyalgia Do Not Satisfy Fibromyalgia Criteria: The 2012 National Health Interview Survey. PLoS One. 2016;11(6):e0157235. PubMed #27281286.  PainSci #53271. The majority of clinically diagnosed fibromyalgia cases in the US do not reach levels of severity necessary and sufficient for diagnosis. The clinical diagnosis of fibromyalgia is disproportionally dependent on demographic and social factors rather than the symptoms themselves. Diagnostic criteria for fibromyalgia appear to be used as a vague guide by clinicians and patients, and allow for substantial diagnostic expansion of fibromyalgia.” BACK TO TEXT
  19. Bäckryd E, Tanum L, Lind AL, Larsson A, Gordh T. Evidence of both systemic inflammation and neuroinflammation in fibromyalgia patients, as assessed by a multiplex protein panel applied to the cerebrospinal fluid and to plasma. J Pain Res. 2017;10:515–525. PubMed #28424559.  PainSci #53589. 

    Although inflammation has been suspected in fibromyalgia, it has been poorly studied to date. This experiment went much further, employing “a new multiplex protein panel enabling simultaneous analysis of 92 inflammation-related proteins.” They looked for these markers in the cerebrospinal spinal fluid and blood of 40 fibromyalgia patients and compared with healthy controls, finding an “extensive inflammatory profile.”

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  20. In theory, the way to tell the difference would be the absence of other classic fibromyalgia symptoms like poor quality sleep, fatigue, memory and mood issues — the infamous “fibrofog.” In practice, those are common, messy, and overlapping sensations (even more so in people who’ve had a lot of aches and pains for years). The sensations in an inflamed person could strongly resemble those in someone with fibromyalgia. BACK TO TEXT
  21. Lasselin J, Kemani MK, Kanstrup M, et al. Low-grade inflammation may moderate the effect of behavioral treatment for chronic pain in adults. J Behav Med. 2016 Oct;39(5):916–24. PubMed #27469518.  PainSci #53548. 

    Forty-one patients with chronic pain (at least six months, many much longer) were tested for signs of systemic inflammation. They all had stable medications, and no major complications. Then they were provided with two kinds of behavioural treatments for several weeks, measuring their progress in several ways.

    Unfortunately, no one did well: “No substantial overall effect of behavioral treatment on pain intensity and pain-related variables was found in the present study.” So that’s a sad result for these behavioural therapies.

    However, there is a scrap of backwards good news here: the patients with more inflammation “were more resistant to the improvement in pain intensity and in psychological variables contributing to pain.” Note that the mechanism of that effect is probably not that inflammation directly makes pain harder to treat, but actually modifies mental state and behaviour and that makes the pain harder to treat.

    The authors believe that this data tentatively “suggests that the inflammatory state may be one of the mechanisms of the persisting behavioral alterations in patients who do not respond to treatment, corresponding to previous studies on treatment resistant depression.”

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  22. And all its cousins: anxiety, insomnia, depression, weak social connections and low social status, and so on. When I refer to “stress” here, I’m talking about any and all of them. BACK TO TEXT
  23. Thompson T, Correll CU, Gallop K, Vancampfort D, Stubbs B. Is Pain Perception Altered in People With Depression? A Systematic Review and Meta-Analysis of Experimental Pain Research. J Pain. 2016 Dec;17(12):1257–1272. PubMed #27589910. 

    Although “clinical studies suggest depressed patients may be more vulnerable to pain,” it’s far from proven. It’s not clear, and it still isn’t after this meta-analysis of 32 studies. The only real finding here was that there’s so much variety in the results of studies that “it depends” in a big way, on many variables.

    This analysis actually found that in some ways depressed patients were less vulnerable to pain — a “small but significant” higher mean sensory threshold and pain threshold — which is interesting but probably not meaningful, given the complexity of the data.

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  24. Elbinoune I, Amine B, Shyen S, et al. Chronic neck pain and anxiety-depression: prevalence and associated risk factors. Pan Afr Med J. 2016;24:89. PubMed #27642428.  PainSci #53545.  BACK TO TEXT
  25. Lasselin J, Alvarez-Salas E, Grigoleit JS. Well-being and immune response: a multi-system perspective. Curr Opin Pharmacol. 2016 Aug;29:34–41. PubMed #27318753.  BACK TO TEXT
  26. Dr. Robert Sapolsky, regarding a study of low-status monkeys (Snyder-Mackler et al), who have really hard lives:

    At the end of the day, being a chronically subordinate nonhuman primate and being a human mired at the bottom of the socioeconomic scale are similar in the most fundamental ways. You have remarkably little control and predictability in your life, your outlets for frustration are limited, and it’s relatively hard to access social support. That’s the prescription for chronic, stress-related maladies.

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  27. Burke 2016, op. cit. BACK TO TEXT
  28. Sapolsky RM. Why Zebras Don’t Get Ulcers. 3rd ed ed. New York: Times Books; 2004. Chapter 8: Immunity, Stress, and Disease; p. 144–185. Sapolsky goes deep on this topic, and I am completely relying on him for this point. I hope I’ve boiled it down to the essentials correctly. His bottom line: “The system apparently did not evolve for dealing with numerous repetitions of coordinating the various on-and-off switches, and ultimately something uncoordinated occurs, increasing the risk that the system becomes autoimmune [inflammatory].” BACK TO TEXT
  29. Gohil BC, Rosenblum LA, Coplan JD, Kral JG. Hypothalamic-pituitary-adrenal axis function and the metabolic syndrome X of obesity. CNS Spectr. 2001 Jul;6(7):581–6, 589. PubMed #15573024.  Prolonged chronic stress can probably contribute to metabolic syndrome by messing with the hormonal balance of the hypothalamic-pituitary-adrenal axis (HPA-axis). BACK TO TEXT
  30. Koren D, Dumin M, Gozal D. Role of sleep quality in the metabolic syndrome. Diabetes Metab Syndr Obes. 2016;9:281–310. PubMed #27601926.  PainSci #53564.  BACK TO TEXT
  31. Carroll JE, Cole SW, Seeman TE, et al. Partial sleep deprivation activates the DNA damage response (DDR) and the senescence-associated secretory phenotype (SASP) in aged adult humans. Brain Behav Immun. 2016 Jan;51:223–9. PubMed #26336034.  PainSci #53312.  “Age-related disease risk has been linked to short sleep duration and sleep disturbances…” BACK TO TEXT
  32. Bower JE, Irwin MR. Mind-body therapies and control of inflammatory biology: A descriptive review. Brain Behav Immun. 2016 Jan;51:1–11. PubMed #26116436.  PainSci #53640. 

    This is a qualitative review of 26 randomized controlled trials of the biological effects of mind-body therapies like Tai Chi, Qigong, yoga, and meditation. The studies show “mixed effects” on inflammation (CRP, IL-6, stimulated cytokine production, etc), and more consistent results for “genomic markers.” Based on this evidence, it seems likely that these activities are meaningfully good for you, and probably helpful for some kinds of chronic pain.

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  33. Bakker EA, Lee DC, Sui X, et al. Association of Resistance Exercise, Independent of and Combined With Aerobic Exercise, With the Incidence of Metabolic Syndrome. Mayo Clin Proc. 2017 Aug;92(8):1214–1222. PubMed #28622914.  PainSci #52977.  “Participating in resistance exercise, even less than 1 hour per week, was associated with a lower risk of development of metabolic syndrome, independent of aerobic exercise. Health professionals should recommend that patients perform resistance exercise along with aerobic exercise to reduce metabolic syndrome.” BACK TO TEXT
  34. Research shows strength training is much more efficient form of exercise than most people realize, and almost any amount of it is much better than nothing. You can gain strength and all its health benefits fairly easily. For more information, see Strength Training Frequency: Less is more than enough: go to the gym less frequently but still gain strength fast enough for anyone but a bodybuilder. BACK TO TEXT
  35. Killer SC, Blannin AK, Jeukendrup AE. No evidence of dehydration with moderate daily coffee intake: a counterbalanced cross-over study in a free-living population. PLoS One. 2014;9(1):e84154. PubMed #24416202.  PainSci #53892.  “These data suggest that coffee, when consumed in moderation by caffeine habituated males provides similar hydrating qualities to water.” BACK TO TEXT
  36. Koopman FA, Chavan SS, Miljko S, et al. Vagus nerve stimulation inhibits cytokine production and attenuates disease severity in rheumatoid arthritis. Proc Natl Acad Sci U S A. 2016 Jul;113(29):8284–9. PubMed #27382171.  PainSci #53670.  BACK TO TEXT
  37. All kinds of data hijinks could be hiding in a study that technical. My main concern is the use of the word “significantly” in the abstract, without any details (effect size in particular). All too often that wording, without clarification, means there was a statistically significant but clinically trivial result. With many treatment trials I can go digging for the effect size to confirm, but not here, the reading is too difficult for me to form any meaningful impression without spending an hour, and even then it might not be clear. And even if the paper does indicate a clinically meaningful result it’s still got “too good to be true” written all over it and may well prove to be difficult to reproduce. BACK TO TEXT
  38. There are two main kinds of pain: nociceptive and neuropathic, or the more familiar pain of tissue damage and the more exotic pain caused by a damaged nervous system. Some pain isn’t easy to classify (fibromyalgia). For more information, see The 3 Basic Types of Pain: Nociceptive, neuropathic, and “other” (and then some more). BACK TO TEXT
  39. Masino SA, Ruskin DN. Ketogenic diets and pain. J Child Neurol. 2013 Aug;28(8):993–1001. PubMed #23680946.  PainSci #53476. 

    ABSTRACT


    Ketogenic diets are well established as a successful anticonvulsant therapy. Based on overlap between mechanisms postulated to underlie pain and inflammation, and mechanisms postulated to underlie therapeutic effects of ketogenic diets, recent studies have explored the ability for ketogenic diets to reduce pain. Here we review clinical and basic research thus far exploring the impact of a ketogenic diet on thermal pain, inflammation, and neuropathic pain.

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