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Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases

updated

Tags: inflam-sys, aging

Four articles on PainSci cite Franceschi 2014: (1) Hydrotherapy, Water-Powered Rehab(2) Complete Guide to Low Back Pain(3) 6 Main Causes of Morning Back Pain(4) Chronic, Subtle, Systemic Inflammation

original abstract Abstracts here may not perfectly match originals, for a variety of technical and practical reasons. Some abstacts are truncated for my purposes here, if they are particularly long-winded and unhelpful. I occasionally add clarifying notes. And I make some minor corrections.

Human aging is characterized by a chronic, low-grade inflammation, and this phenomenon has been termed as inflammaging. Inflammaging is a highly significant risk factor for both morbidity and mortality in the elderly people, as most if not all age-related diseases share an inflammatory pathogenesis. Nevertheless, the precise etiology of inflammaging and its potential causal role in contributing to adverse health outcomes remain largely unknown. The identification of pathways that control age-related inflammation across multiple systems is therefore important in order to understand whether treatments that modulate inflammaging may be beneficial in old people. The session on inflammation of the Advances in Gerosciences meeting held at the National Institutes of Health/National Institute on Aging in Bethesda on October 30 and 31, 2013 was aimed at defining these important unanswered questions about inflammaging. This article reports the main outcomes of this session.

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