What works for stubborn aches, pains, and injuries?
And what doesn’t? And why? PainScience.com explores the surprisingly weird science of many kinds of chronic pain and injury, from fibromyalgia to runner’s knee. The site is a library of a couple deep-dive articles for both patients and healthcare professionals, informal but heavily referenced and constantly updated for 20 years. Like it says on the tin, there’s a pro-science bias here, and quackery is kicked to the curb. More.
Why the salamander? More mascot than logo, the salamander’s astonishing regenerative biology is a symbol of healing. More.

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What hurts? The most popular guides to specific conditions
- When to Worry About Neck Pain … and when not to! — Tips, checklists, and non-scary possible explanations for neck pain.
- A Deep Dive into Delayed-Onset Muscle Soreness — The biology & treatment of the “muscle fever” that follows intense exercise.
- The Complete Guide to IT Band Syndrome — Everything you could possibly want to know about the most common type of runner’s knee.
- 6 Main Causes of Morning Back Pain — Why is back pain worst first thing in the morning?
- A Rational Guide to Fibromyalgia — All about the mysterious disease of pain, exhaustion, and mental fog.
- Cramps, Spasms, Tremors & Twitches — The biology and treatment of unwanted muscle contractions.
- Complete Guide to Frozen Shoulder — Exploring one of the strangest of all common musculoskeletal conditions.
- INDEX of 52 CONDITION GUIDES
What works? The most popular treatment reviews
- Quite a Stretch — The most popular form of therapeutic exercise… has few actual benefits.
- Does Epsom Salt Work? — The science and mythology of Epsom salt bathing as a tonic for pain & injury.
- Trigger Point Therapy — All about the strange therapeutic art of… pressing on sore spots?
- Strength Training Frequency — Strength training is surprisingly efficient, good medicine.
- The Chiropractic Controversies — A tour of far too many chiropractic controversies.
- Does Platelet-Rich Plasma Injection Work? — Nope. The first popular “regenerative” therapy is bogus.
- Zapped! Does TENS work for pain? — Electrical stimulation is perpetually popular, which is weird.
- See also compilations of the most proven pain treatments, as well as a much wider range of more speculative options (but still safer and more plausible).
- INDEX of 92 TREATMENT REVIEWS

Yes, but why? Articles about key concepts and principles of pain
- Pain is Weird — Pain is trickster, a volatile and misleading sensation.
- Your Back Is Not Out of Alignment — Debunking the obsession with alignment and biomechanics.
- MRI Worse than Useless for Back Pain — The legacy of the false alarm machines!
- Is Running on Pavement Risky? — Hard-surface running might be a risk factor for running injuries. It’s surprising hard to tell.
- Sensitization — Pain can change how pain works… and never for the better.
- INDEX of 55 ARTICLES ABOUT CONCEPTS
The blog & newsletter: pain science news, highlights, and musings
The PainScience.com blog is the “director’s commentary” for the site.
- Sep 22: Stretching to … build muscle? It works, but there’s a catch!
- Sep 19: Cannabis hype control
- Sep 14: Follow-up: The details of that strength training protocol that didn’t work for knee pain
- Sep 12: More study not always needed
- Sep 7: Can neck massage stimulate the vagus nerve? For better or worse? (Member Post)
- INDEX of 1100 POSTS
What’s new? Article updates
A steady stream of content improvements and corrections are all logged, like on Wikipedia.
- Sep 21: low back pain +Rewritten, back pain as an overuse injury — Like-new re-write. Before: simplistic and old-school by my 2023 standards. After: not very scientifically rigorous, but much more informed and wide-ranging speculation. And kinda fun.
The Complete Guide to Low Back Pain - Sep 20: cannabis for pain +Added a citation to Gedin on the role of placebo, poor blinding, and media buzz.
Marijuana for Pain - Sep 18: how we stand up +Added a fresh citation (first note) about the number of cells we have: roughly thirty trillion, according to a new paper.
Ten Trillion Cells Walked Into a Bar - Sep 7: opioids for musculoskeletal pain +Edited. Made several minor clarifications, most notably emphasizing that opioids are indeed effective for some kinds of chronic pain (despite being surprisingly ineffective for so many others).
Opioids for Chronic Aches & Pains - Sep 2: skepticism about “trigger points” +Added a very substantial (bloated?) new footnote, in which I (finally) provide my best guesses for “what really happened” in a trigger point therapy success story. There’s also a blog post.
Trigger Point Doubts - INDEX of MANY MORE UPDATES

You’ve got a lot of reading to do! Sorry it’s all here on the computer …
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