
Dupuytren’s contracture, showing significant progression of tendon fibrosis, pulling the finger into permanent flexion.
Dupuytren’s Contracture
The tip of a mysterious pathological iceberg
Dupuytren’s contracture causes a slow and mostly painless thickening of the connective tissue (fascia) and tendons of the palm. It starts in the palm — the earliest sign is a triangular puckering of the skin — and creeps towards the fingers, mostly the ring and pinkie fingers, which flex permanently. The hand will not lie flat on a table, as though it has an arch like a foot. In the most extreme cases, the finger bones can fuse and warp.
This disease is mostly genetic, mainly affecting aging white men. But it has a list of other risk factors and triggers like alcoholism, being skinny, hand injuries, diabetes, and smoking of course (it seems to be a risk factor for everything). But the biggest risk factor, and most interesting, is working with vibrating tools.
Dupuytren’s contracture (DC) has no other common name: just the tricky one, the legacy of French anatomist Guillaume Dupuytren (du-pwee-TREN), who first described it in 1883.1 Much more descriptively it sometimes also goes by palmar fascia fibromatosis or palmar fibromas. Or, more cryptically, it is known as Viking disease.2 Bagpipers call it the “Curse of the MacCrimmons.”3 But the eponymous mouthful is by far the dominant label.
A family of related, odd diseases
Whatever causes Dupuytren’s contracture also affects some other tissues. About half of people with frozen shoulder also have DC,4 for instance. There are also similar related troubles in:
- the knuckles (Garrod’s pads)
- the foot (Ledderhose disease, which has nothing to do with plantar fasciitis, somewhat surprisingly given that they both concern the same tissue)
- and, rather alarmingly, the penis (Peyronie’s disease).5 😮
Most people only have one of these variants, but they probably are all driven by the same biological glitch — it’s just a matter of which tissue is affected.6
If you have one, it does increase the risk of the others. A few people get more than one of them, because they have more of whatever the underlying biological malfunction is. When this worst-case scenario happens, it’s called Dupuytren’s Diathesis. It hits earlier, moves faster, and affects more fingers and probably both hands.
Diathesis makes it very clear that each of these diseases is the tip of a pathological iceberg. A biological cure is needed.
There is no cure for Dupuytren’s contracture, but there are treatments
You can’t stop a biological process you don’t understand. The malfunction at the root of Dupuytren’s contracture is still unexplained and therefore untreatable. However, some of its consequences can be partially managed in some patients.
In the early stages, or post-surgically, the condition might be slowed by a use-it-or-lose approach: exercise and stretching, primarily.
Ordinary stretching for contractures is definitely not effective,7 so it would be a happy surprise if Dupuytren’s contracture was an exception. Splinting is a little more promising, and there’s evidence it works for some other conditions.8 For all-night stretching, you can use a splint to keep the hand from flexing when you sleep. There are many types available commercially, and you can make your own.9 Splinting appeared to be at least partially effective in a tiny 2012 study, one of the few scientific tests of this treatment ever published10… but (of course) that’s contradicted by a larger, better study.11 It’s a long shot, with the saving grace that there’s little to lose by trying.
Steroid injections might suppress the immune system activity (inflammation) that drives the disease, but this is a bit unlikely. Also more-or-less untested — it’s just one of those “might make sense” treatments.
Treating it like a tumour and bombarding the palm with radiation can kill the cells that produce the excess tissue. There are some serious side effects to this, of course, so it had better work; unfortunately, it’s really not clear that it does.12
Collegenase, an enzyme, dissolves connective tissue; injecting the right amount in the right place can dissolve the thickened cords that shorten the palm. The effectiveness is fairly well-established,13 but the side effects are a real concern.
Finally, the connective tissue of the palm can be cut or lacerated to loosen it. This, at least, is virtually guaranteed to have at least some beneficial effect — but even simple surgeries have risks, and recurrence of the condition after surgery is common.
Alternative medicine loves to offer (mostly ridiculous) treatments for incurable conditions, but the only notable one for Dupuytren’s contracture is vitamin E. Alas, it’s quite unlikely that it works.14 If it did, it probably wouldn’t be considered “alternative.”
Shockwave therapy for Dupuytren’s contracture

Shockwave therapy in action — though not for Dupuytren’s contracture, obviously.
Working with vibrating tools is the major non-genetic risk factor for Dupuytren’s contracture. So shockwave therapy is an ironic treatment, because it is — dramatic pause, because this twist deserves it — basically just vibration therapy.
A scientific review says it works though. So … checkmate, irony!
Shockwave therapy is a sibling of ultrasound, but uses pressure waves: low frequency but fast, high energy waves that smack into tissue much harder than sound waves. This makes it even more closely related to massage guns, and with the same vague goal of stimulating tissue.15 It’s just a potent vibration, applied to Dupuytren’s because it has a reputation for being good for many orthopedic conditions for unclear reasons — a reputation that is not even deserved!16
Of course, there are many kinds of vibration.17 And clearly a few brief doses of shockwave therapy is not really the same as years of pushing a lawn mower. But I still say it’s odd, ironic, and not entirely risk-free to blast a vibration-triggered disease with more vibrations.
So, do shocking waves help people with Dupuytren’s? The thin science says “yes!”
Yazdani et al. auditioned twenty-six studies, tossed out twenty, and analyzed the remaining six.18 These were all really small studies, with only 145 patients covered by all of them — just a couple dozen people per trial on average. But studies don’t have to be big to be good, and these researchers judged five to be “good” quality, and one “fair.” I think they might have been a bit too generous. Which is not an uncommon problem with little reviews of a small body of evidence.
But — good news, everyone! — those six studies of uncertain quality collectively showed “remarkable improvement” in pain and function, as measured by the pain-scale and various disability questionnaires. One study also reported improved grip.
And another reported actual shrinkage of the distinctive bumps and lumps of Dupuytren’s contracture! So maybe shockwave therapy can “melt” contractures somehow? That would be a way bigger deal than merely improving pain and function — that’s changing the course of the disease. If it really does, that’s some crazy physiology, fascinating and important. But I rather doubt it. And so do Yazdani et al., who rated their confidence in that evidence “low.” (Even though it came from a study they rated as “fair”? Seems like a bit of a contradiction there.)
The review concludes (with some slightly stilted English):
"Shockwave therapy can lead to significant pain improvement, functional rehabilitation, and patient satisfaction with no adverse effect in the management of Dupuytren disease. Pain may return over time, but not to that severity [sic] before the intervention."
I do not trust this result, nor other similar reviews.19 However, it is both an interesting and strongly positive take, so there you have it — for whatever it’s worth.
I used to rely on meta-analysis, but they are worse than laws & sausages, ceasing to inspire respect in proportion as we know how they are made.
Dr. Mark Crislip, "I Never Meta Analysis I Really Like"
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About Paul Ingraham

I am a science writer in Vancouver, Canada. I was a Registered Massage Therapist for a decade and the assistant editor of ScienceBasedMedicine.org for several years. I’ve had many injuries as a runner and ultimate player, and I’ve been a chronic pain patient myself since 2015. Full bio. See you on Facebook or Twitter., or subscribe:
What’s new in this article?
2017 — More detail and references about stretching. Miscellaneous editing.
2017 — Publication.
Notes
- As is so often the case, it was actually “discovered” (described) by someone else long before that: Henry Cline, in 1808. See “Cline’s Contracture: Dupuytren Was a Thief – A History of Surgery for Dupuytren’s Contracture.”
- Because Northern European men are most affected, though it is actually common throughout the Mediterranean.
- The MacCrimmons were a family of well-known bagpipe players in 16th Century Scotland. Dupuytren’s contracture makes it impossible to pipe, and the condition is relatively common in Europeans. However, inflammatory arthritis is so much more common that I wonder how the curse ended up referring to such a relatively obscure condition!
- Smith SP, Devaraj VS, Bunker TD. The association between frozen shoulder and Dupuytren's disease. J Shoulder Elbow Surg. 2001;10(2):149–51. PubMed 11307078 ❐
- Peyronie’s is very rare, but I have a friend who was stricken with it. Beating the odds, his troubling deformity actually regressed — a stroke of luck that only a small fraction of the afflicted enjoy. Presumably it is also possible for some cases of DC to regress.
- This is a microcosm of a broader pattern in rheumatology. There are dozens of autoimmune diseases, but basically all of them involve the same process applied to different types of tissues in specific locations. Nearly any tissue in the body can be damaged by an overzealous immune system, creating dramatically different effects. There may be variation in how the immune system damages tissues as well, and DC might be a sub-type of autoimmune disease.
- Harvey LA, Katalinic OM, Herbert RD, et al. Stretch for the treatment and prevention of contractures. Cochrane Database Syst Rev. 2017 Jan;1:CD007455. PubMed 28146605 ❐ PainSci Bibliography 52742 ❐
This is a Cochrane review of static stretch for the treatment and prevention of contractures. The verdict? A clear thumbs down. Based on “high-quality evidence” they concluded that “stretch is not effective for the treatment and prevention of contractures.”
- Furia JP, Willis FB, Shanmugam R, Curran SA. Systematic review of contracture reduction in the lower extremity with dynamic splinting. Adv Ther. 2013 Aug;30(8):763–70. PubMed 24018464 ❐ PainSci Bibliography 52971 ❐
- Glue a glove to a thin but sturdy sheet of wood, metal, or plastic, to keep the hand flat as you sleep.
- Larocerie-Salgado J, Davidson J. Nonoperative treatment of PIPJ flexion contractures associated with Dupuytren's disease. J Hand Surg Eur Vol. 2012 Oct;37(8):722–7. PubMed 21965179 ❐
- Jerosch-Herold C, Shepstone L, Chojnowski AJ, et al. Night-time splinting after fasciectomy or dermo-fasciectomy for Dupuytren's contracture: a pragmatic, multi-centre, randomised controlled trial. BMC Musculoskelet Disord. 2011 Jun;12:136. PubMed 21693044 ❐ PainSci Bibliography 52736 ❐
150 patients received physical therapy for their Dupuytren’s contracture, with or without night splint usage. There was no difference by any measure, and so “routine addition of night-time splinting for all patients after fasciectomy or dermofasciectomy is not recommended.”
- Kadhum M, Smock E, Khan A, Fleming A. Radiotherapy in Dupuytren's disease: a systematic review of the evidence. J Hand Surg Eur Vol. 2017 Mar:1753193417695996. PubMed 28490266 ❐ “On balance, radiotherapy should be considered an unproven treatment for early Dupuytren's disease due to a scarce evidence base and unknown long-term adverse effects. Well-designed randomized controlled studies are required to confirm the benefits of radiotherapy treatment.”
- Gaston RG, Larsen SE, Pess GM, et al. The Efficacy and Safety of Concurrent Collagenase Clostridium Histolyticum Injections for 2 Dupuytren Contractures in the Same Hand: A Prospective, Multicenter Study. J Hand Surg Am. 2015 Oct;40(10):1963–71. PubMed 26216077 ❐ “Collagenase clostridium histolyticum can be used to effectively treat 2 affected joints concurrently without a greater risk of AEs than treatment of a single joint, with the exception of skin laceration.”
- Richards HJ. Dupuytren's contracture treated with vitamin E. Br Med J. 1952 Jun;1(4772):1328. PubMed 14935247 ❐ PainSci Bibliography 52875 ❐
ABSTRACT
A series of 46 cases of Dupuytren’s contracture were treated; 24 had bilateral lesions. The patients were divided into three groups according to the degree of the deformity. Vitamn E was the sole form of treatment, and in no case was any improvement noted.
This topic has barely been studied in the decades since this experiment. - No one really knows why shockwave therapy would work for this, so the plausibility is quite low. And there are technical problems with getting valid statistical significance about unlikely effects (see Pandolfi et al.).
- There’s mostly just an absence of evidence, and what evidence we do have is — as usual — cherry-picked and over-rated by the many professionals who sell shockwave therapy, and sincerely don’t want to read the fine print. For the details, see my full guide to ultrasound and shockwave therapy.
- Music is all just vibrations, but ranges from inspiring genius to ear-stabbing torture. I’m fine with the way my electric toothbrush vibrates, but the ultrasonic scaler at the dentist is Satan’s work.
- Yazdani A, Nasri P, Baradaran Mahdavi S. The Effects of Shock Wave Therapy on the Symptoms and Function of Individuals With Dupuytren Disease: A Systematic Review. Arch Phys Med Rehabil. 2024 Oct;105(10):1985–1992. PubMed 38866227 ❐
There’s a nearly identical 2022 review from different authors at the same Iranian institution, and also a positive 2018 review out of Turkey. Surely three positive reviews is enough for evidence-based medicine? Not really. Junky little reviews are just as common as junky little trials these days, and the garbage-in-garbage-out problem is immense.
Related: a 2016 meta-analysis of six trials of shockwave therapy for Peyronie’s disease found that it “may” improve pain and penile plaques, but definitely “not improving of penile curvature and sexual function” (which is of course what Peyronie’s patients care about the most).