Eleven articles on PainSci cite Moseley 2002: 1. Extraordinary Health Claims 2. The Complete Guide to IT Band Syndrome 3. Complete Guide to Low Back Pain 4. The Complete Guide to Patellofemoral Pain Syndrome 5. Complete Guide to Plantar Fasciitis 6. The Complete Guide to Neck Pain & Cricks 7. Your Back Is Not Out of Alignment 8. Should You Get A Lube Job for Your Arthritic Knee? 9. Do Nerve Blocks Work for Neck Pain and Low Back Pain? 10. Knee Surgery Sure is Useless! 11. Does Cartilage Regeneration Work?
PainSci commentary on Moseley 2002: ?This page is one of thousands in the PainScience.com bibliography. It is not a general article: it is focused on a single scientific paper, and it may provide only just enough context for the summary to make sense. Links to other papers and more general information are provided wherever possible.
This is landmark and fascinating study showed that people with osteoarthritis improved equally well regardless of whether they received a genuine surgical procedure or a sham.
From the abstract: “In this controlled trial involving patients with osteoarthritis of the knee, the outcomes after arthroscopic lavage or arthroscopic debridement were no better than those after a placebo procedure.”
Two decades later, this isn’t quite so surprising anymore — many similar studies have been done since — but it was a truly amazing result at that time. It is a particularly striking example of the placebo effect and implies that belief can have an effect even on seemingly “mechanical” problems.
In 2008, these specific results were fully supported by a Cochrane Collaboration review (Laupattarakasem) which concluded that “there is ‘gold’ level evidence that arthoscopic debridement has no benefit,” and by New England Journal of Medicine (Kirkley) which reported that “surgery for osteoarthritis of the knee provides no additional benefit to optimized physical and medical therapy.”
Surgeries have always been surprisingly based on tradition, authority, and educated guessing rather than good scientific trials; as they are tested properly, compared to a placebo (a sham surgery), many are failing. Moseley 2002 was the first of many to compare orthopedic (“carpentry”) surgeries to shams. By 2016, at least four more such procedures had been shown to have no benefit (Louw 2016), and that trend has continued since.
The need for placebo-controlled trials of surgeries (and the damning results) is explored in much greater detail — and very readably — in the excellent 2016 book, Surgery: The ultimate placebo, by Ian Harris.
~ Paul Ingraham
original abstract †Abstracts here may not perfectly match originals, for a variety of technical and practical reasons. Some abstacts are truncated for my purposes here, if they are particularly long-winded and unhelpful. I occasionally add clarifying notes. And I make some minor corrections.
BACKGROUND: Many patients report symptomatic relief after undergoing arthroscopy of the knee for osteoarthritis, but it is unclear how the procedure achieves this result. We conducted a randomized, placebo-controlled trial to evaluate the efficacy of arthroscopy for osteoarthritis of the knee.
METHODS: A total of 180 patients with osteoarthritis of the knee were randomly assigned to receive arthroscopic debridement, arthroscopic lavage, or placebo surgery. Patients in the placebo group received skin incisions and underwent a simulated debridement without insertion of the arthroscope. Patients and assessors of outcome were blinded to the treatment-group assignment. Outcomes were assessed at multiple points over a 24-month period with the use of five self-reported scores--three on scales for pain and two on scales for function--and one objective test of walking and stair climbing. A total of 165 patients completed the trial.
RESULTS: At no point did either of the intervention groups report less pain or better function than the placebo group. For example, mean (+/-SD) scores on the Knee-Specific Pain Scale (range, 0 to 100, with higher scores indicating more severe pain) were similar in the placebo, lavage, and debridement groups: 48.9+/-21.9, 54.8+/-19.8, and 51.7+/-22.4, respectively, at one year (P=0.14 for the comparison between placebo and lavage; P=0.51 for the comparison between placebo and debridement) and 51.6+/-23.7, 53.7+/-23.7, and 51.4+/-23.2, respectively, at two years (P=0.64 and P=0.96, respectively). Furthermore, the 95 percent confidence intervals for the differences between the placebo group and the intervention groups exclude any clinically meaningful difference.
CONCLUSIONS: In this controlled trial involving patients with osteoarthritis of the knee, the outcomes after arthroscopic lavage or arthroscopic debridement were no better than those after a placebo procedure.
- “Arthroscopic debridement for knee osteoarthritis,” W Laupattarakasem, M Laopaiboon, P Laupattarakasem, and C Sumananont, Cochrane Database of Systematic Reviews, 2008.
- “A Randomized Trial of Arthroscopic Surgery for Osteoarthritis of the Knee,” Alexandra Kirkley, Trevor B Birmingham, Robert B Litchfield, J Robert Giffin, Kevin R. Willits, Cindy J. Wong, Brian G. Feagan, Allan Donner, Sharon H Griffin, Linda M D’Ascanio, Janet E Pope, and Peter J Fowler, New England Journal of Medicine, 2008.
- “A Systematic Review of Clinical Outcomes in Patients Undergoing Meniscectomy,” Michael J Salata, Aimee E Gibbs, and Jon K Sekiya, American Journal of Sports Medicine, 2010.
- “Sham Surgery in Orthopedics: A Systematic Review of the Literature,” Adriaan Louw, Ina Diener, César Fernández-de-Las-Peñas, and Emilio J Puentedura, Pain Med, 2016.
- Surgery: The ultimate placebo (book), by Ian Harris (book review).
This page is part of the PainScience BIBLIOGRAPHY, which contains plain language summaries of thousands of scientific papers & others sources. It’s like a highly specialized blog. A few highlights:
- Photobiomodulation therapy is not better than placebo in patients with chronic nonspecific low back pain: a randomised placebo-controlled trial. Guimarães 2021 Pain.
- No effect of creatine monohydrate supplementation on inflammatory and cartilage degradation biomarkers in individuals with knee osteoarthritis. Cornish 2018 Nutr Res.
- The CANBACK trial: a randomised, controlled clinical trial of oral cannabidiol for people presenting to the emergency department with acute low back pain. Bebee 2021 Med J Aust.
- Relationships Between Sleep Quality and Pain-Related Factors for People with Chronic Low Back Pain: Tests of Reciprocal and Time of Day Effects. Gerhart 2017 Ann Behav Med.
- Modulation in the elastic properties of gastrocnemius muscle heads in individuals with plantar fasciitis and its relationship with pain. Zhou 2020 Sci Rep.