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bibliography * The PainScience Bibliography contains plain language summaries of thousands of scientific papers and others sources, like a specialized blog. This page is about a single scientific paper in the bibliography, Medzhitov 2008.

Origin and physiological roles of inflammation

Medzhitov R. Origin and physiological roles of inflammation. Nature. 2008 Jul;454(7203):428–35. PubMed #18650913.
Tags: inflammation, classics, biology, deep, etiology, pain problems, pro

PainSci summary of Medzhitov 2008?This page is one of thousands in the bibliography. It is not a general article: it is focused on a single scientific paper, and it may provide only just enough context for the summary to make sense. Links to other papers and more general information are provided at the bottom of the page, as often as possible. ★★★★★?5-star ratings are for sentinel studies, excellent experiments with meaningful results. Ratings are a highly subjective opinion, and subject to revision at any time. If you think this paper has been incorrectly rated, please let me know.

Fascinating high-level tour of the subject of inflammation, highlighting the extreme diversity of biomarkers and processes, and many still blank spots on the science map. Particularly relevant to musculoskeletal health, Medhitov explains that the “inflammation” going on in tissues that are chronically stressed — as in repetitive strain injury — are basically mysterious and quite different from the “classic” inflammatory response we see in infection and trauma, and “It is unclear how applicable knowledge of infection-induced inflammation is to other types of inflammation.” Highly recommended reading for professionals.

~ Paul Ingraham

original abstract

Inflammation underlies a wide variety of physiological and pathological processes. Although the pathological aspects of many types of inflammation are well appreciated, their physiological functions are mostly unknown. The classic instigators of inflammation — infection and tissue injury — are at one end of a large range of adverse conditions that induce inflammation, and they trigger the recruitment of leukocytes and plasma proteins to the affected tissue site. Tissue stress or malfunction similarly induces an adaptive response, which is referred to here as para-inflammation. This response relies mainly on tissue-resident macrophages and is intermediate between the basal homeostatic state and a classic inflammatory response. Para-inflammation is probably responsible for the chronic inflammatory conditions that are associated with modern human diseases.

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These three articles on cite Medzhitov 2008 as a source:

This page is part of the PainScience BIBLIOGRAPHY, which contains plain language summaries of thousands of scientific papers & others sources. It’s like a highly specialized blog. A few highlights: