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Origin and physiological roles of inflammation

PainSci » bibliography » Medzhitov 2008
updated
Tags: inflammation, classics, biology, deep, etiology, pain problems, pro

Six articles on PainSci cite Medzhitov 2008: 1. The Complete Guide to IT Band Syndrome2. The Complete Guide to Patellofemoral Pain Syndrome3. Complete Guide to Plantar Fasciitis4. Pseudo-Quackery in the Treatment of Pain5. Repetitive Strain Injuries Tutorial6. Massage Does Not Reduce Inflammation

PainSci summary of Medzhitov 2008: ?This page is one of thousands in the PainScience.com bibliography. It is not a general article: it is focused on a single scientific paper, and it may provide only just enough context for the summary to make sense. Links to other papers and more general information are provided wherever possible.

Fascinating high-level tour of the subject of inflammation, highlighting the extreme diversity of biomarkers and processes, and many still blank spots on the science map. Particularly relevant to musculoskeletal health, Medhitov explains that the “inflammation” going on in tissues that are chronically stressed — as in repetitive strain injury — are basically mysterious and quite different from the “classic” inflammatory response we see in infection and trauma, and “It is unclear how applicable knowledge of infection-induced inflammation is to other types of inflammation.” Highly recommended reading for professionals.

~ Paul Ingraham

original abstract Abstracts here may not perfectly match originals, for a variety of technical and practical reasons. Some abstacts are truncated for my purposes here, if they are particularly long-winded and unhelpful. I occasionally add clarifying notes. And I make some minor corrections.

Inflammation underlies a wide variety of physiological and pathological processes. Although the pathological aspects of many types of inflammation are well appreciated, their physiological functions are mostly unknown. The classic instigators of inflammation — infection and tissue injury — are at one end of a large range of adverse conditions that induce inflammation, and they trigger the recruitment of leukocytes and plasma proteins to the affected tissue site. Tissue stress or malfunction similarly induces an adaptive response, which is referred to here as para-inflammation. This response relies mainly on tissue-resident macrophages and is intermediate between the basal homeostatic state and a classic inflammatory response. Para-inflammation is probably responsible for the chronic inflammatory conditions that are associated with modern human diseases.

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