Educated guesses
Paul Ingraham • ARCHIVEDMicroblog posts are archived and rarely updated. In contrast, most long-form articles on PainScience.com are updated regularly over the years.
Ideas based only on educated guessing about biology, however reasonable and plausible they may sound, have a nasty habit of falling apart when more directly tested. This is one of the strongest patterns in the history of medicine.
A classic modern example is autologous blood injections for tendonitis: an idea that sounds promising if you just talk about the biology, but fails when tested on actual patients.
