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Variability in training-induced skeletal muscle adaptation

PainSci » bibliography » Timmons 2011
Tags: exercise, self-treatment, treatment

One article on PainSci cites Timmons 2011: Strength Training Frequency

PainSci notes on Timmons 2011:

The results of training muscle are unpredictable, and these authors believe it is of “great medical importance that some individuals do not substantially physiologically adapt to exercise training.”

original abstract Abstracts here may not perfectly match originals, for a variety of technical and practical reasons. Some abstacts are truncated for my purposes here, if they are particularly long-winded and unhelpful. I occasionally add clarifying notes. And I make some minor corrections.

When human skeletal muscle is exposed to exercise training, the outcomes, in terms of physiological adaptation, are unpredictable. The significance of this fact has long been underappreciated, and only recently has progress been made in identifying some of the molecular bases for the heterogeneous response to exercise training. It is not only of great medical importance that some individuals do not substantially physiologically adapt to exercise training, but the study of the heterogeneity itself provides a powerful opportunity to dissect out the genetic and environmental factors that limit adaptation, directly in humans. In the following review I will discuss new developments linking genetic and transcript abundance variability to an individual's potential to improve their aerobic capacity or endurance performance or induce muscle hypertrophy. I will also comment on the idea that certain gene networks may be associated with muscle adaptability regardless the stimulus provided.

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