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Vitamin D for the treatment of chronic painful conditions in adults

PainSci » bibliography » Straube et al 2015
updated
Tags: treatment, vitamin D, chronic pain, nutrition, self-treatment, pain problems

One article on PainSci cites Straube 2015: Vitamin D for Pain

PainSci commentary on Straube 2015: ?This page is one of thousands in the PainScience.com bibliography. It is not a general article: it is focused on a single scientific paper, and it may provide only just enough context for the summary to make sense. Links to other papers and more general information are provided wherever possible.

This is a review of 10 generally poor quality studies of vitamin D supplementation intended to treat a variety of painful problems. It concludes that “a large beneficial effect of vitamin D across different chronic painful conditions is unlikely,” but a general effect on a variety of conditions was never plausible to begin with. As for whether it helps specific painful conditions, that, of course, “needs further investigation.” This is the same conclusion reached by > in 2016.

~ Paul Ingraham

original abstract Abstracts here may not perfectly match originals, for a variety of technical and practical reasons. Some abstacts are truncated for my purposes here, if they are particularly long-winded and unhelpful. I occasionally add clarifying notes. And I make some minor corrections.

MAIN RESULTS: We included six new studies (517 participants) in this review update, bringing the total of included studies to 10 (811 participants). The studies were heterogeneous with regard to study quality, the chronic painful conditions that were investigated, the dose of vitamin D given, co-interventions, and the outcome measures reported. Only two studies reported responder pain outcomes; the other studies reported treatment group average outcomes only. Overall, there was no consistent pattern that vitamin D treatment was associated with greater efficacy than placebo in any chronic painful condition (low quality evidence). Adverse events and withdrawals were comparatively infrequent, with no consistent difference between vitamin D and placebo (good quality evidence).

AUTHORS' CONCLUSIONS: The evidence addressing the use of vitamin D for chronic pain now contains more than twice as many studies and participants than were included in the original version of this review. Based on this evidence, a large beneficial effect of vitamin D across different chronic painful conditions is unlikely. Whether vitamin D can have beneficial effects in specific chronic painful conditions needs further investigation.

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