How risky are NSAIDS?

https://sciencebasedpharmacy.wordpress.com/2015/07/25/how-risky-are-ns [snip!]
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PainSci notes

A good general discussion of painkiller risks and side effects, but the relative safety of topical treatments is of particular interest:

The main advantage of topical NSAIDs is the reduced exposure of the rest of the body to the product, which reduces the side effect profile. Given the toxicity of NSAIDs is related in part to the dose, it follows that topical treatments should have a better toxicity profile. Consequently, the cardiovascular risks of topical diclofenac, even in those with a high baseline risk of disease, should be negligible with the topical forms.

~ Paul Ingraham, PainSci Publisher

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“FDA Strengthens Warning of Heart Attack and Stroke Risk for Non-Steroidal Anti-Inflammatory Drugs,” FDA.gov.

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