One article on PainSci cites Reilly 2018: Ten Trillion Cells Walked Into a Bar
original abstract †Abstracts here may not perfectly match originals, for a variety of technical and practical reasons. Some abstacts are truncated for my purposes here, if they are particularly long-winded and unhelpful. I occasionally add clarifying notes. And I make some minor corrections.
Mechanobiology – the discipline that focuses on the key role that mechanical forces contribute to control of biological structure and function across all size scales – requires application of multi-disciplinary approaches. These approaches span multiple fields including materials science, physics, chemistry, biology, engineering, medicine and computational modeling. Mechanobiology has been significantly advanced by the cellular tensegrity theory. This theory proposes that living systems use principles of tensegrity architecture to govern how molecules self-assemble to create multi-molecular structures, organelles, cells, tissues, organs and living organisms. Use of tensegrity provides a mechanism to control shape stability while maintaining tight integration between structure and function. It also enables mechanical information transfer from the macro-scale to the nanoscale, where mechano-chemical transduction can occur at the molecular level. While various experiments have provided data in support of the use of tensegrity by biological systems, it has not been possible to visualize how these architectural principles are utilized to build hierarchical structures of various sizes and complexity that undergo dynamic changes in form and mechanics within living cells. We recently described a new advance in multi-scale molecular simulation that combined molecular dynamic simulation methods with physics-based animation approaches, which showed how mechanical forces and deformations generated at the molecular level propagate across size scales to drive directional movement of whole cells, using sperm motility as an example (Reilly and Ingber, ACS Nano 2017, 11:12156–12166). These computer simulations also confirmed that tensegrity principles are indeed utilized at the level of individual molecules, multi-molecular assemblages, and whole living cells. Here, we explore these previous findings in greater detail in relation to tensegrity, and also describe how this simulation strategy can be used to model coupling of enzyme substrate concentrations to multiscale tensegrity-based force transduction, using mitochondrial ATP synthase as an example.
Specifically regarding Reilly 2018:
This page is part of the PainScience BIBLIOGRAPHY, which contains plain language summaries of thousands of scientific papers & others sources. It’s like a highly specialized blog. A few highlights:
- No long-term effects after a three-week open-label placebo treatment for chronic low back pain: a three-year follow-up of a randomized controlled trial. Kleine-Borgmann 2022 Pain.
- Exercise and education versus saline injections for knee osteoarthritis: a randomised controlled equivalence trial. Bandak 2022 Ann Rheum Dis.
- Association of Lumbar MRI Findings with Current and Future Back Pain in a Population-based Cohort Study. Kasch 2022 Spine (Phila Pa 1976).
- A double-blinded randomised controlled study of the value of sequential intravenous and oral magnesium therapy in patients with chronic low back pain with a neuropathic component. Yousef 2013 Anaesthesia.
- Is Neck Posture Subgroup in Late Adolescence a Risk Factor for Persistent Neck Pain in Young Adults? A Prospective Study. Richards 2021 Phys Ther.