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Getting It Wrong on Chronic Fatigue Syndrome

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Julie Rehmeyer and David Tuller
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November 18

PainSci notes

The huge but notoriously flawed PACE trial seemed to support the idea that chronic fatigue syndrome patients are just de-conditioned and therefore need to suck it up and exercise, slowly building themselves back up again. This was evidence-based medicine at its very worst: one low quality but influential study drowning out both contradictory evidence and patient voices. It has become the most extreme example of telling sick people that their illness is “all in your head.” Julie Rehmeyer and David Tuller’s NYT piece is the canonical summary of the whole debacle.

~ Paul Ingraham, PainSci Publisher

Related Content

  1. “Uninterpretable: Fatal flaws in PACE Chronic Fatigue Syndrome,” James Coyne,
  2. “PACE trial claims for recovery in myalgic encephalomyelitis/chronic fatigue syndrome - true or false? It's time for an independent review of the methodology and results,” Shepherd, J Health Psychol, 2017.
  3. “Trial by Error: The Troubling Case of the PACE Chronic Fatigue Syndrome Study,” David Tuller,

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  7. Treating PIS and long Covid

PainSci Member Login » Submit your email to unlock member content. If you can’t remember/access your registration email, please contact me. ~ Paul Ingraham, PainSci Publisher