Letter to the Editor: Pumping the Brakes on the Biochemical Milieu of Myofascial Trigger Points
Two pages on PainSci cite Moraska 2024: 1. Toxic Muscle Knots
PainSci notes on Moraska 2024:
A 2024 letter to the journal that published Shah in 2008, expressing concern and urging “caution when referencing these studies” — basically because they think the results always were suspiciously surprising, and the technique used to achieve them was novel, difficult, and likely error-prone.
The response from Shah et al. response is thoughtful and detailed and calls for replication.
Arguably these concerns always seemed obvious to any critical thinker, and apply to literally any unreplicated study with surprising results.
For detailed analysis, see “Trigger points debate greatly delayed (Member Post).”
related content
Specifically regarding Moraska 2024:
Moraska 2024 is about:
- “An in vivo microanalytical technique for measuring the local biochemical milieu of human skeletal muscle,” Shah et al, Journal of Applied Physiology, 2005.
- “Biochemicals associated with pain and inflammation are elevated in sites near to and remote from active myofascial trigger points,” Shah et al, Archives of Physical Medicine & Rehabilitation, 2008.
This page is part of the PainScience BIBLIOGRAPHY, which contains plain language summaries of thousands of scientific papers & others sources. It’s like a highly specialized blog. A few highlights:
- Classical Conditioning Fails to Elicit Allodynia in an Experimental Study with Healthy Humans. Madden 2017 Pain Med.
- Topical glyceryl trinitrate (GTN) and eccentric exercises in the treatment of mid-portion achilles tendinopathy (the NEAT trial): a randomised double-blind placebo-controlled trial. Kirwan 2024 Br J Sports Med.
- Placebo analgesia in physical and psychological interventions: Systematic review and meta-analysis of three-armed trials. Hohenschurz-Schmidt 2024 Eur J Pain.
- Recovery trajectories in common musculoskeletal complaints by diagnosis contra prognostic phenotypes. Aasdahl 2021 BMC Musculoskelet Disord.
- Cannabidiol (CBD) products for pain: ineffective, expensive, and with potential harms. Moore 2023 J Pain.