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Arginine-initiated release of human growth hormone. Factors modifying the response in normal man

PainSci » bibliography » Merimee et al 1969
Tags: treatment, self-treatment, medications, exercise, nutrition

One article on PainSci cites Merimee 1969: Vitamins, Minerals & Supplements for Pain & Healing

PainSci notes on Merimee 1969:

Some ancient, basic physiology science demonstrating that arginine supplementation may stimulated production of growth hormone — which is still used by as a rationale for arginine supplementation for bodybuilders to this day.

original abstract Abstracts here may not perfectly match originals, for a variety of technical and practical reasons. Some abstacts are truncated for my purposes here, if they are particularly long-winded and unhelpful. I occasionally add clarifying notes. And I make some minor corrections.

To improve the usefulness of testing pituitary function by the response of human growth hormone (HGH) to I.V. arginine loads, arginine infusions were given under a variety of conditions to healthy subjects aged 17 to 35. The minimum effective arginine load causing release of HGH was 1/6 gm per pound of body weight in men and 1/12 gm per pound of body weight in women. At each of three dosage schedules used, women responded with greater increases in plasma HGH than men. Treatment of men with diethylstilbestrol augmented their HGH response to arginine, whereas methyltestosterone pretreatment did not decrease the response in women. The HGH response to arginine was not abolished by acute hyperglycemia but was attenuated or delayed by a previous stimulus for HGH release.

In the use of this test of pituitary function, it is necessary to use a proper dose of arginine, to avoid other stimuli of HGH release, and to pretreat men with estrogens.

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