Two articles on PainSci cite McCabe 2016: 1. The Complete Guide to Trigger Points & Myofascial Pain 2. Vitamin D for Pain
PainSci commentary on McCabe 2016: ?This page is one of thousands in the PainScience.com bibliography. It is not a general article: it is focused on a single scientific paper, and it may provide only just enough context for the summary to make sense. Links to other papers and more general information are provided wherever possible.
This study measured vitamin D levels in more than 2300 older European men in good health and then checked up on them a few years later. If they had low vitamin D at the beginning, they were more likely to have chronic widespread pain later. However, that connection got much weaker when they eliminated obese and depressed patients from consideration. Obesity and depression are known, confirmed risk factors for chronic pain. The study concluded: “Low vitamin D is linked with the new occurrence of chronic widespread pain, although this may be explained by underlying adverse health factors, particularly obesity and depression.”
This study is one of about a dozen others investigating a link between chronic pain and vitamin D deficiency, reviewed by Hsiao et al. Notably, in most studies the link is clear even after adjusting for other factors.
~ Paul Ingraham
original abstract †Abstracts here may not perfectly match originals, for a variety of technical and practical reasons. Some abstacts are truncated for my purposes here, if they are particularly long-winded and unhelpful. I occasionally add clarifying notes. And I make some minor corrections.
BACKGROUND: The association between low levels of vitamin D and the occurrence of chronic widespread pain (CWP) remains unclear. The aim of our analysis was to determine the relationship between low vitamin D levels and the risk of developing CWP in a population sample of middle age and elderly men.
METHODS: Three thousand three hundred sixty nine men aged 40-79 were recruited from 8 European centres for a longitudinal study of male ageing, the European Male Ageing Study. At baseline participants underwent assessment of lifestyle, health factors, physical characteristics and gave a fasting blood sample. The occurrence of pain was assessed at baseline and follow up (a mean of 4.3 years later) by shading painful sites on a body manikin. The presence of CWP was determined using the ACR criteria for fibromyalgia. Serum 25-hydroxyvitamin D (25-(OH) D) was assessed by radioimmunoassay. Logistic regression was used to determine the relationship between baseline vitamin D levels and the new occurrence of CWP.
RESULTS: Two thousand three hundred thirteen men, mean age 58.8 years (SD = 10.6), had complete pain and vitamin data available and contributed to this analysis. 151 (6.5%) developed new CWP at follow up and 577 (24.9%) were pain free at both time points, the comparator group. After adjustment for age and centre, physical performance and number of comorbidities, compared to those in upper quintile of 25-(OH) D ( ≥36.3 ng/mL), those in the lowest quintile (<15.6 ng/mL) were more likely to develop CWP (Odds Ratio [OR] = 1.93; 95% CI = 1.0-3.6). Further adjustment for BMI (OR = 1.67; 95% CI = 0.93-3.02) or depression (OR = 1.77; 95% CI = 0.98-3.21), however rendered the association non-significant.
CONCLUSIONS: Low vitamin D is linked with the new occurrence of chronic widespread pain, although this may be explained by underlying adverse health factors, particularly obesity and depression.
- “Is Serum Hypovitaminosis D Associated with Chronic Widespread Pain Including Fibromyalgia? A Meta-analysis of Observational Studies,” Ming-Yen Hsiao, Chen-Yu Hung, Ke-Vin Chang, Der-Sheng Han, and Tyng-Guey Wang, Pain Physician, 2015.
- “Effect of Vitamin D Supplementation on Pain: A Systematic Review and Meta-analysis,” Zhenqiang Wu, Zarintaj Malihi, Alistair W Stewart, Carlene Mm Lawes, and Robert Scragg, Pain Physician, 2016.
This page is part of the PainScience BIBLIOGRAPHY, which contains plain language summaries of thousands of scientific papers & others sources. It’s like a highly specialized blog. A few highlights:
- No long-term effects after a three-week open-label placebo treatment for chronic low back pain: a three-year follow-up of a randomized controlled trial. Kleine-Borgmann 2022 Pain.
- Exercise and education versus saline injections for knee osteoarthritis: a randomised controlled equivalence trial. Bandak 2022 Ann Rheum Dis.
- Association of Lumbar MRI Findings with Current and Future Back Pain in a Population-based Cohort Study. Kasch 2022 Spine (Phila Pa 1976).
- A double-blinded randomised controlled study of the value of sequential intravenous and oral magnesium therapy in patients with chronic low back pain with a neuropathic component. Yousef 2013 Anaesthesia.
- Is Neck Posture Subgroup in Late Adolescence a Risk Factor for Persistent Neck Pain in Young Adults? A Prospective Study. Richards 2021 Phys Ther.