Statin-Associated Autoimmune Myopathy
PainSci summary of Mammen 2016?This page is one of thousands in the PainScience.com bibliography. It is not a general article: it is focused on a single scientific paper, and it may provide only just enough context for the summary to make sense. Links to other papers and more general information are provided at the bottom of the page, as often as possible. ★★★☆☆?3-star ratings are for typical studies with no more (or less) than the usual common problems. Ratings are a highly subjective opinion, and subject to revision at any time. If you think this paper has been incorrectly rated, please let me know.
A good review of the phenomenon of muscle pain caused by statins, the popular and important drugs we take to lower cholesterol. For more information, see Dr. Harriet Hall’s reporting on the paper, or my summary of the issue in 32 Surprising Causes of Pain.
original abstract†Abstracts here may not perfectly match originals, for a variety of technical and practical reasons. Some abstacts are truncated for my purposes here, if they are particularly long-winded and unhelpful. I occasionally add clarifying notes. And I make some minor corrections.
Statins are widely used and lower the risk of death from cardiovascular causes. In a fraction of patients, an autoimmune myopathy may develop, characterized by the development of autoantibodies to the target enzyme, HMG-CoA reductase.
related content
- “Statin Therapy: Risks vs Benefit: An Expert Interview With Eliot A. Brinton, MD,” Linda Brookes, Medscape CME.
- “Effects of Statins on Skeletal Muscle: A Perspective for Physical Therapists,” Stephanie L Di Stasi, Toran D Macleod, Joshua D Winters, and Stuart A Binder-Macleod, Physical Therapy, 2010.
- “A systematic review of statin-induced muscle problems in clinical trials,” Harsha V Ganga, Hanna B Slim, and Paul D Thompson, Am Heart J, 2014.
Specifically regarding Mammen 2016:
These two articles on PainScience.com cite Mammen 2016 as a source:
- PS Trigger Points & Myofascial Pain Syndrome — A guide to the unfinished science of muscle pain, with reviews of every theory and self-treatment and therapy option
- PS 32 Surprising Causes of Pain — Trying to understand pain when there is no obvious explanation
This page is part of the PainScience BIBLIOGRAPHY, which contains plain language summaries of thousands of scientific papers & others sources. It’s like a highly specialized blog. A few highlights:
- A Bayesian model-averaged meta-analysis of the power pose effect with informed and default priors: the case of felt power. Gronau 2017 Comprehensive Results in Social Psychology.
- The neck and headaches. Bogduk 2014 Neurol Clin.
- Agreement of self-reported items and clinically assessed nerve root involvement (or sciatica) in a primary care setting. Konstantinou 2012 Eur Spine J.
- Effect of NSAIDs on Recovery From Acute Skeletal Muscle Injury: A Systematic Review and Meta-analysis. Morelli 2017 Am J Sports Med.
- Association of Spinal Manipulative Therapy With Clinical Benefit and Harm for Acute Low Back Pain: Systematic Review and Meta-analysis. Paige 2017 JAMA.