original abstract†Abstracts here may not perfectly match originals, for a variety of technical and practical reasons. Some abstacts are truncated for my purposes here, if they are particularly long-winded and unhelpful. I occasionally add clarifying notes. And I make some minor corrections.
BACKGROUND: Obesity is associated with an increased risk of developing osteoarthritis (OA), even in non-weight bearing joints. High levels of adipose tissue-associated inflammation may explain this association. SOURCES OF DATA AND AREAS OF DEBATE: Published evidence looking at the associations between components of Metabolic Syndrome (MetS) and knee, hip or hand OA and the higher mortality described with knee OA. EMERGING POINTS: Development of MetS and OA shares a relationship with adipose tissue-associated inflammation. This review supports this inflammatory pathway being part of the shared mechanism behind obesity as a risk factor for OA and the recently described OA-associated increased mortality. TIMELY AREAS FOR DEVELOPMENT: In an era of an obesity epidemic, this review identifies a need for well-designed cohort studies assessing early metabolic changes in populations at high risk of OA and MetS, and to identify risk factors for increased mortality in patients with OA.
- “Knee osteoarthritis has doubled in prevalence since the mid-20th century,” Ian J Wallace, Steven Worthington, David T Felson, Robert D Jurmain, Kimberly T Wren, Heli Maijanen, Robert J Woods, and Daniel E Lieberman, Proc Natl Acad Sci U S A, 2017.
- “Body mass index and hand osteoarthritis susceptibility: an updated meta-analysis,” Liying Jiang, Xiaohua Xie, Yidan Wang, Yingchen Wang, Yihua Lu, Tian Tian, Minjie Chu, and Yi Shen, Int J Rheum Dis, 2016.
This page is part of the PainScience BIBLIOGRAPHY, which contains plain language summaries of thousands of scientific papers & others sources. It’s like a highly specialized blog. A few highlights:
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