PainSci summary of Holman 2015?This page is one of thousands in the PainScience.com bibliography. It is not a general article: it is focused on a single scientific paper, and it may provide only just enough context for the summary to make sense. Links to other papers and more general information are provided at the bottom of the page, as often as possible. ★★★☆☆3-star ratings are for typical studies with no more (or less) than the usual common problems. Ratings are a highly subjective opinion, and subject to revision at any time. If you think this paper has been incorrectly rated, please let me know.
This paper presents evidence “minor” irritation of the upper spinal cord may cause “potent sympathetic arousal in humans” — firing up the same branch of our nervous system that handles emergencies. Thirty-one of fifty-four patients with fibromyalgia and positional cervical cord compression showed clear signs of sympathatic arousal.
original abstract†Abstracts here may not perfectly match originals, for a variety of technical and practical reasons. Some abstacts are truncated for my purposes here, if they are particularly long-winded and unhelpful. I occasionally add clarifying notes. And I make some minor corrections.
In 1998, C Muhle and D Resnick proposed a corollary to cervical spinal stenosis caused by intermittent abutment of the cervical spinal cord from dynamic shifting of degenerative discs with flexion and extension of the neck. This positional cervical cord compression (PC3) has been documented in 54-71% of patients with fibromyalgia (FM) and was an exclusion criterion in the pramipexole FM randomized controlled trial. In animal models, PC3 is a potent sympathetic nervous system arousal.
In humans, PC3 is so difficult to distinguish from FM (without dynamic imaging) that its validity and impact have been questioned. Given PC3 and FM symptom overlap, a blinded study was conducted.
Methods: Patients diagnosed with fibromyalgia per American College of Rheumatology 1990 classification criteria were recruited from the Seattle area and after consent, were provided standard, non-contrast cervical spine magnetic resonance imaging (MRI) with two additional sagittal flexion and extension views with spinal canal diameter measurement at each disc level. PC3 was defined by a canal narrowing below 10 mm at any level WITH clear visual abutment of the cervical spinal cord by the commensurate disc and ligamentum flavum2.
Double-blinded to the MRI results, subjects were assessed by history, physical examination, and a variety of surveys, including the Multidimensional Health Assessment Questionnaire (MDHAQ), Fibromyalgia Impact Questionnaire (FIQ), Short Form Health Survey (SF-36), Epworth Sleepiness Scale (ESS), Fatigue Severity Scale (FSS), Health Assessment Questionnaire (HAQ), 16-item Quick Inventory of Depressive Symptoms (QIDS) as well as autonomic nervous system (ANS) assessment by 5-minute, frequency domain, heart rate variability (HRV) of parasympathetic, sympathetic and total power measures (Omegawave Ltd, Espoo, Finland). Statistical analysis was conducted using Wilcoxon rank-sum for continuous variables and Fisher’s exact test for categorical variables.
Results: Fifty-four patients with FM participated in this study (92% women, mean age 45.2 years). PC3 was identified in 31 of 54 subjects (57.4%). All three ANS HRV measures demonstrated statistical significance. Consistent with animal model data, parasympathetic score was lower 0.145 ± 0.067 for PC3+ patients and higher 0.198 ± 0.098 for PC3- patients (p=0.029). Sympathetic score was higher 61.0 ± 17.5 for PC3+ patients and lower 46.2 ± 15.8 for PC3- patients (p=0.005). Total power score was lower 440 ± 492 for PC3+ patients and higher 1633 ±4232 for PC3- patients (p=0.022). No clinical, historical or survey measures distinguished PC3-FM+ patients from PC3+FM+ patients.
Conclusion: This study provides the first evidence that intermittent, positional abutment of the cervical cord is a potent sympathetic arousal in humans. It also highlights the challenge of diagnosing and addressing PC3 without imaging. Further investigation will to sort out the role of PC3 in the diagnostic conundrum of FM, its pathogenesis and its treatment algorithms.
- “Positional cervical spinal cord compression and fibromyalgia: a novel comorbidity with important diagnostic and treatment implications,” Andrew J Holman, Journal of Pain, 2008.
- “Clinical evidence for cervical myelopathy due to Chiari malformation and spinal stenosis in a non-randomized group of patients with the diagnosis of fibromyalgia,” Dan S Heffez, Ruth E Ross, Yvonne Shade-Zeldow, Konstantinos Kostas, Sagar Shah, Robert Gottschalk, Dean A Elias, Alan Shepard, Sue E Leurgans, and Charity G Moore, European Spine Journal, 2004.
- “Treatment of cervical myelopathy in patients with the fibromyalgia syndrome: outcomes and implications,” Dan S Heffez, Ruth E Ross, Yvonne Shade-Zeldow, Konstantinos Kostas, Mary Morrissey, Dean A Elias, and Alan Shepard, European Spine Journal, 2007.
Specifically regarding Holman 2015:
- “Using Dynamic MRI to Diagnose Neck Pain: The Importance of Positional Cervical Cord Compression (PC3),” Andrew Holman, PracticalPainManagement.com.
These three articles on PainScience.com cite Holman 2015 as a source:
- PS Anxiety & Chronic Pain — A self-help guide for people who worry and hurt
- PS Trigger Points & Myofascial Pain Syndrome — A guide to the unfinished science of muscle pain, with reviews of every theory and self-treatment and therapy option
- PS 34 Surprising Causes of Pain — Trying to understand pain when there is no obvious explanation
This page is part of the PainScience BIBLIOGRAPHY, which contains plain language summaries of thousands of scientific papers & others sources. It’s like a highly specialized blog. A few highlights:
- Effectiveness of customised foot orthoses for Achilles tendinopathy: a randomised controlled trial. Munteanu 2015 Br J Sports Med.
- A Bayesian model-averaged meta-analysis of the power pose effect with informed and default priors: the case of felt power. Gronau 2017 Comprehensive Results in Social Psychology.
- The neck and headaches. Bogduk 2014 Neurol Clin.
- Agreement of self-reported items and clinically assessed nerve root involvement (or sciatica) in a primary care setting. Konstantinou 2012 Eur Spine J.
- Effect of NSAIDs on Recovery From Acute Skeletal Muscle Injury: A Systematic Review and Meta-analysis. Morelli 2017 Am J Sports Med.