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bibliography*The PainScience Bibliography contains plain language summaries of thousands of scientific papers and others sources, like a specialized blog. This page is about a single scientific paper in the bibliography, Holick 2003.

Vitamin D deficiency: what a pain it is


Tags: chronic pain, vitamin D, muscle pain, etiology, treatment, nutrition, self-treatment, pain problems, muscle, pro

PainSci summary of Holick 2003?This page is one of thousands in the bibliography. It is not a general article: it is focused on a single scientific paper, and it may provide only just enough context for the summary to make sense. Links to other papers and more general information are provided at the bottom of the page, as often as possible. ★★☆☆☆?2-star ratings are for studies with flaws, bias, and/or conflict of interest; published in lesser journals. Ratings are a highly subjective opinion, and subject to revision at any time. If you think this paper has been incorrectly rated, please let me know.

In this editorial for Mayo Clinic Proceedings, Holick explains that “Vitamin D deficiency causes muscle weakness and muscle aches and pains in both children and adults.” In reference to Plotnikoff et al, who studied the relationship between D and pain directly and produced quite dramatic data, “The association between nonspecific musculoskeletal pain and vitamin D deficiency was suspected because of a higher prevalence of these symptoms during winter than summer. The study patients ranged in age from 10 to 65 years, and all had symptoms of vitamin D deficiency. Of the more than 90% of patients who were medically evaluated for persistent musculoskeletal pain 1 year or more before screening, none had been tested previously for vitamin D deficiency.”

original abstractAbstracts here may not perfectly match originals, for a variety of technical and practical reasons. Some abstacts are truncated for my purposes here, if they are particularly long-winded and unhelpful. I occasionally add clarifying notes. And I make some minor corrections.

In the current issue of the Mayo Clinic Proceedings, Plotnikoff and Quigley report that 100% of African Americans, East Africans, Hispanics, and American Indians in their Minnesota-based study had deficient levels of vitamin D; overall, 93% of the 150 children and adults in the study, which included broad categories of ethnic groups, were vitamin D–deficient. Is this unexpected? No. Is this newsworthy? Yes.

related content

These two articles on cite Holick 2003 as a source:

This page is part of the PainScience BIBLIOGRAPHY, which contains plain language summaries of thousands of scientific papers & others sources. It’s like a highly specialized blog. A few highlights: