Characteristics of skeletal muscle strength in subjects with interstitial lung disease
Two pages on PainSci cite Garcia 2024: 1. Strength Training for Pain & Injury Rehab 2. Common lung dysfunction makes people weaker
PainSci notes on Garcia 2024:
This experiment tested the muscle strength in 112 people with interstitial lung disease (a general failure of lung function with many possible causes). The subjects were compared to 48 healthy adults, finding that they were about 25% weaker on average. For instance, the quadriceps muscles were 58–87% as strong as they were without ILD, with an average of 72%. Lower body muscles were generally weaker, and the triceps was the least affected muscle at 84%. Only a handful of subjects with ILD matched the strength of the healthy controls in any muscle. “Adults with ILD present a generalised reduction in peripheral muscle strength,” the authors concluded.
original abstract †Abstracts here may not perfectly match originals, for a variety of technical and practical reasons. Some abstacts are truncated for my purposes here, if they are particularly long-winded and unhelpful. I occasionally add clarifying notes. And I make some minor corrections.
OBJECTIVES: To investigate muscle strength and the prevalence of muscle weakness in adults with interstitial lung diseases compared to healthy subjects.
DESIGN: Cross-sectional (description of clinical features) SETTING: Public referral centre (University Hospital)
PARTICIPANTS: One hundred and twelve adults with interstitial lung disease (ILD, n=48, 60±10yr, 68% female) and healthy counterparts (control group, n=64, 57±10yr, 58% female)
INTERVENTION: Not applicable.
MAIN OUTCOME MEASURE(S): Muscle strength and prevalence of muscle weakness in adults with ILD. Muscle strength was assessed via maximal isometric voluntary contraction of dominant upper and lower limb muscle groups. Data from the control group were used to generate reference equations. Muscle weakness was defined as a muscle strength value below the lower limit of normal calculated using data from the control group. Data were expressed as mean ± standard deviation or median [interquartile range] according to the data distribution.
RESULTS: Compared to the control group, adults with ILD had lower muscle strength for all muscle groups assessed (values presented as %predicted: pectoralis major 75[57-86]%; quadriceps 72[58-87]%; latissimus dorsi 76[57-103]%; deltoid 74[64-98]%; biceps brachii 78[64-91]%; triceps brachii 84[62-101]%; p≤0.001 for all). Prevalence of muscle weakness in people with ILD was 40% for pectoralis major, 25% for latissimus dorsi, 16% for triceps brachii, 20% for biceps brachii, 27% for deltoid and 46% for quadriceps.
CONCLUSION: Adults with ILD present a generalised reduction in peripheral muscle strength, ranging between 20% to 46% of people depending on the muscle group assessed. and it was more prevalent in lower limb muscles.
related content
- “COVID-19 and interstitial lung diseases: A multifaceted look at the relationship between the two diseases,” Fukihara et al, Respir Investig, 2023.
This page is part of the PainScience BIBLIOGRAPHY, which contains plain language summaries of thousands of scientific papers & others sources. It’s like a highly specialized blog. A few highlights:
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