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Pregabalin for neuropathic pain in adults

PainSci » bibliography » Derry et al 2019

Three articles on PainSci cite Derry 2019: 1. The Complete Guide to Trigger Points & Myofascial Pain2. The Complete Guide to Low Back Pain3. Neuropathies Are Overdiagnosed

PainSci notes on Derry 2019:

This The Cochrane Collaboration review of pregabalin (Lyrica) has a clearly positive conclusion: it appears to be efficacious for postherpetic and diabetic neuralgia, plus also “mixed or unclassified post-traumatic neuropathic pain.” However, results vary widely from one person to the next, and “many will have no benefit.” All drugs are like this to some extent, of course, but the response to anti-convulsants for neuropathy seems to be particularly varied.

original abstract Abstracts here may not perfectly match originals, for a variety of technical and practical reasons. Some abstacts are truncated for my purposes here, if they are particularly long-winded and unhelpful. I occasionally add clarifying notes. And I make some minor corrections.

BACKGROUND: This review updates part of an earlier Cochrane Review titled "Pregabalin for acute and chronic pain in adults", and considers only neuropathic pain (pain from damage to nervous tissue). Antiepileptic drugs have long been used in pain management. Pregabalin is an antiepileptic drug used in management of chronic pain conditions.

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AUTHORS' CONCLUSIONS: Evidence shows efficacy of pregabalin in postherpetic neuralgia, painful diabetic neuralgia, and mixed or unclassified post-traumatic neuropathic pain, and absence of efficacy in HIV neuropathy; evidence of efficacy in central neuropathic pain is inadequate. Some people will derive substantial benefit with pregabalin; more will have moderate benefit, but many will have no benefit or will discontinue treatment. There were no substantial changes since the 2009 review.

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