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Failure of magnesium sulphate to prevent suxamethonium induced muscle pains

PainSci » bibliography » Chestnutt et al 1985
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Two articles on PainSci cite Chestnutt 1985: 1. The Complete Guide to Trigger Points & Myofascial Pain2. Does Epsom Salt Work?

PainSci commentary on Chestnutt 1985: ?This page is one of thousands in the bibliography. It is not a general article: it is focused on a single scientific paper, and it may provide only just enough context for the summary to make sense. Links to other papers and more general information are provided wherever possible.

Muscle pain is one of the side effects of suxamethonium chloride, an anaesthetic drug used to cause short-term paralysis. In this study, injecting magnesium sulphate had no benefit compared to doing nothing, and was “followed by unpleasant side effects.“

~ Paul Ingraham

original abstract Abstracts here may not perfectly match originals, for a variety of technical and practical reasons. Some abstacts are truncated for my purposes here, if they are particularly long-winded and unhelpful. I occasionally add clarifying notes. And I make some minor corrections.

In fit unpremedicated patients undergoing minor operations and who were ambulant on the afternoon of the operations, pretreatment with magnesium sulphate given intravenously did not reduce the incidence of suxamethonium [anaesthetic] induced myalgia below that in a similar series who received no prophylactic therapy. The injection of magnesium in conscious patients is followed by unpleasant side effects.

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