PainSci summary of Bogduk 2010?This page is one of thousands in the PainScience.com bibliography. It is not a general article: it is focused on a single scientific paper, and it may provide only just enough context for the summary to make sense. Links to other papers and more general information are provided at the bottom of the page, as often as possible. ★★★★★5-star ratings are for sentinel studies, excellent experiments with meaningful results. Ratings are a highly subjective opinion, and subject to revision at any time. If you think this paper has been incorrectly rated, please let me know.
Excellent analysis of the potential importance of an amazing study of methylene blue injections for discogenic low back pain (see Peng).
original abstract†Abstracts here may not perfectly match originals, for a variety of technical and practical reasons. Some abstacts are truncated for my purposes here, if they are particularly long-winded and unhelpful. I occasionally add clarifying notes. And I make some minor corrections.
In esteemed disciplines of science, such as physics, truth is not defined by a single publication. If a laboratory announces a new discovery, it is standard practice for other laboratories to promptly replicate the study, in order to confirm or refute its observations. The discovery does not become fact until at least one other laboratory confirms the observations, but preferably there should be multiple, independent confirmations. This principle should apply to the results reported by Peng et al. in this issue .
Peng et al.  announced astounding results, unprecedented and unrivalled in the history of research into the treatment of chronic discogenic low back pain. The treatment was simply an injection of 1ml of 1% methylene blue and 1ml of 2% lignocaine. In a randomized, placebo-controlled trial this treatment achieved reductions of mean scores from 72 to 20 for pain, and from 48 to 13 for disability. Some 19% of their patients achieved complete relief of pain, at 24months, with a further 72% having only slight pain that required no medication. For these outcomes the number needed to treat was 2. Against these figures, the results of surgery, rehabilitation, behavioural therapy, and any other treatment for back pain pale into insignificance.
One article on PainScience.com cites Bogduk 2010 as a source:
- PS Save Yourself from Low Back Pain! — Low back pain myths debunked and all your treatment options reviewed
This page is part of the PainScience BIBLIOGRAPHY, which contains plain language summaries of thousands of scientific papers & others sources. It’s like a highly specialized blog. A few highlights:
- A Bayesian model-averaged meta-analysis of the power pose effect with informed and default priors: the case of felt power. Gronau 2017 Comprehensive Results in Social Psychology.
- The neck and headaches. Bogduk 2014 Neurol Clin.
- Agreement of self-reported items and clinically assessed nerve root involvement (or sciatica) in a primary care setting. Konstantinou 2012 Eur Spine J.
- Effect of NSAIDs on Recovery From Acute Skeletal Muscle Injury: A Systematic Review and Meta-analysis. Morelli 2017 Am J Sports Med.
- Association of Spinal Manipulative Therapy With Clinical Benefit and Harm for Acute Low Back Pain: Systematic Review and Meta-analysis. Paige 2017 JAMA.