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The discriminative value of inflammatory back pain in patients with persistent low back pain

PainSci » bibliography » Arnbak et al 2016
Tags: diagnosis, back pain, arthritis, imaging, pain problems, spine, aging

Two articles on PainSci cite Arnbak 2016: 1. The Complete Guide to Low Back Pain2. 6 Main Causes of Morning Back Pain

PainSci notes on Arnbak 2016:

This study confirms that inflammatory back pain and morning back pain are related, but also that the relationship is not strong or exclusive.

82% of more than 700 patients with chronic low back pain reported “morning stiffness” — practically everyone! — but only 11% actually had spondyloarthritis (according to ASAS criteria). Only 10% felt that their pain was worst in the morning. Although these and other inflammatory back pain signs were significantly associated with spondyloarthritis, there’s just too much overlap with other kinds of back pain for morning symptoms to actually identify spondyloarthritis.

original abstract Abstracts here may not perfectly match originals, for a variety of technical and practical reasons. Some abstacts are truncated for my purposes here, if they are particularly long-winded and unhelpful. I occasionally add clarifying notes. And I make some minor corrections.

OBJECTIVES: To estimate the prevalence of inflammatory back pain (IBP) characteristics and analyse the discriminative value of IBP relative to axial spondyloarthritis (SpA) according to the Assessment of SpondyloArthritis international Society (ASAS) criteria.

METHOD: Patients who had low back pain for> 3 months were selected from a cohort of secondary care patients aged 18-40 years. Data included information on SpA features, human leucocyte antigen (HLA)-B27 typing, C-reactive protein (CRP) level, magnetic resonance imaging (MRI) of the sacroiliac joints, and self-reported IBP questions covering the pain characteristics included in the Calin, Berlin, and ASAS IBP definitions.

RESULTS: Of the 759 included patients, 99% [95% confidence interval (CI) 98-100] had at least one IBP characteristic. The prevalence of the single IBP characteristics ranged from 10% (95% CI 7-12) for 'pain worst in the morning' to 79% (95% CI 76-82) for 'morning stiffness'. Two-thirds of the patients (67%, 95% CI 63-70), met at least one of the three IBP definitions. In all, 86 (11%) were classified as 'SpA according to ASAS'. All three IBP definitions were significantly associated with 'SpA according to ASAS'; however, the discriminative value was low, with sensitivity, specificity, and balanced accuracy values of 64, 50, and 57% for Calin, 59, 60, and 60% for Berlin, and 35, 79, and 57% for ASAS IBP definitions, respectively.

CONCLUSIONS: In this study population, IBP characteristics were in general common and the discriminative value was low, as IBP could not differentiate patients with SpA according to ASAS criteria from patients with other causes of back pain.

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